Bromgexin tablets Instructions for use. Tablets "Bromgexine" for children: instructions for use. Application during pregnancy and in breastfeeding period

Bromgexin He is a bright representative of a group of mucolithics and secret-chief drugs. It is a synthetic analogue of the plant called Justice Vascular, however, with less pronounced side effects compared with the extract of this plant. Due to the special structure of bromgexine molecules and its metabolites, it is capable of simplifying the structure of mucopolysaccharides of mucus. In other words, the drug contributes to the "spinning" molecules of mucopolysaccharides and through this - a decrease in their ability to capture water molecules. As this ability decreases, the mucus is loss.

In addition to this impact on the mucus, bromgexin is able to influence both cells producing it. The result of this impact is the formation of a larger number of less viscous mucus, as well as an increase in surfactant products in the lungs. The surfactant is a substance necessary in order for the lungs of the lungs after the exhalation. In the absence of a surfactant, a state appears, called respiratory distress syndrome. It is manifested by the progressive shortness of breath, the formation of skin and mucousproof coverings and, ultimately, the death of the patient with unwise of appropriate medical care.

The third effect of the drug lies in its ability to stimulate the elimination of the resulting liquid sputum through the increase in the oscillatory movements of the recreation epithelium. As a result, the mucus accumulates in the lumen of large bronchi and the trachea with a large number of cough receptors. Excess of sputum annoys the aforementioned receptors and there is a reflector flipping of the mucus, accompanied by its removal from the bronchial trees.

Bromgexine has high bioavailability. In other words, this drug is able to penetrate absolutely into all the tissues of the body, overcoming all biological barriers. In accordance with the foregoing, the drug is contraindicated pregnant in the second and third trimester, as well as nursing mothers, because it may disrupt the process of forming the lungs of both the fetus and a born baby. However, if the disease is directly the child, the use of the drug is justified.

Types of medicine, commercial names of analogs, output

Bromgexine is produced in the form of the following dosage forms:

pills;
dragee;
elixir;
syrup;
drops for reception inside ( ingestion).

Tablets and dragee can be used both adults and children from two years old and older. For children of little age, it is recommended to use droplets for intro, syrup and elixira due to the fact that with their help it is easier to dose the drug as opposed to tablets. In 1 ml of a solution for receiving inside of the syrup and elixir are 0.8 mg of active substance.

Bromgexin meets in pharmacies under the following commercial names:

Bromgexin Berlin Hemi;
Flagamine;
Bronchostop;
Solvin;
Bromgexin Ratiopharm;
Bromgraxin-Egis and others.

Company manufacturers Bromgexin

Firm manufacturer	Commercial name drug	Producing country	Form release	Dosage
*Berlin-Chemie.*	*Bromgexin 4 Berlin Hemi*	Germany	Ingestion (4 mg in 1 ml of solution)	INsorrowand children Older 14 years, the drug is prescribed at a dose of 8 - 16 mg ( 10 - 20 ml of medicine) 3 times a day. The drug is prescribed at a dose of 8 mg ( 10 ml) 3 times a day. *Children under 6 years* The drug is prescribed at a dose of 2 - 4 mg ( 2.5 and 5 ml) 3 times a day.
*Berlin-Chemie.*	*Bromgexin 8 Berlin Hemi*	Germany	Dragee. (8 mg / drage)	*Adults and children* The drug is prescribed in an amount of 8 - 16 mg ( 1 - 2 dragee) 3 times a day. *Children from 6 to 14 years old and patients with body weight less than 50 kg* The drug is shown in an amount of 8 mg ( 1 dragee.) 3 times a day. *Children up to 6 years* 2 - 4 mg ( half or quarter of dragee) 3 times a day. However, in view of the fact that the use of syrups, elixirs and solutions for receiving inside is recommended for children under 6 years of age.
*Pharbita.*	*Bromgexin*	Netherlands	Pills (8 mg)	The drug is prescribed at a dose of 8 - 16 mg ( 1 - 2 tablets) 3 times a day. *Children from 6 to 14 years* The preparation is shown in an amount of 8 mg ( 1 Tablet) 3 times a day. *Children up to 6 years* 2 - 4 mg ( half and quarter tablets) 3 times a day.
*Pharmstandart-lexere*	*Bromgexin*	Russia	Pills (8 mg)
*Pliva Krakow.*	*Flegamine*	Poland	Syrup (2 - 4 mg / 5 ml)	*Children up to 6 years* Showing from 2 to 4 mg of the drug 3 times a day. *Children from 6 to 14 years old and patients with body weight less than 50 kg* The drug is shown at a dose of 8 mg 3 times a day. *Children over 14 years old and adult* It is shown the prescription of the drug in an amount of 8 - 16 mg 3 times a day.
*Vave International*	*Bromgexin Elixir*	India	Elixir (4 mg / 5 ml)	*Adults and children over 14 years old* prescribed at a dose of 8 - 16 mg ( 10 - 20 ml). *Children from 6 to 14 years old and patients with body weight less than 50 kg* - 8 mg ( 10 ml) 3 times a day. *Children up to 6 years* - 2 - 4 mg ( 2.5 and 5 ml).

Mechanism of therapeutic action of medication

Finding into the gastrointestinal tract, bromgexine almost completely penetrates blood and applies throughout the body. The maximum concentration of the drug in the blood is achieved after two hours. As bromgexin falls into the liver, it takes gradual adjustment to the formation of intermediate metabolites, also possessing pronounced musolitic and secretory action. The most famous metabolite bromgexin is the drug called Ambroxol. Bromgexin is a drug that can accumulate in tissues, so the initial lowered effect occurs after 2 - 4 hours after the first application, and the maximum effect develops from 4 to 5 days of treatment.

Both bromgexine and its metabolites affect both the mucus and the cells producing it. Due to the fact that this drug is not able to selectively affect the respiratory epithelium, its effects applies to the remaining mucous cells of the body. This feature explains some side effects of bromgexin described below. In addition, the drug is capable of penetrating through the biological barriers of the body - the hematorencephalic, hematoplascent, as well as in maternal milk, and therefore bromgexine is contraindicated in pregnant women in the second and third trimester in the normal course of pregnancy, as well as nursing mothers. In the first trimester, the use of the drug is allowed, since the intensive development of the pulmonary fabric of the fetus begins approximately from the fifth month of intrauterine development. With the appearance of acute necessity in the appointment of drugs of this group of nursing mother, the child must be transferred to artificial feeding during its treatment.

In contact with the mucus, bromgexine affects the mucopolysaccharides, which are included in its composition, and "spins" them, simplifying the structure of the latter. As the structure simplifies the structure, the ability of mucopolysaccharides to bind water molecules, which is externally manifested by a decrease in the viscosity of the mucus. When contact with mucus-forming cells, bromgexine is connected to specific receptors on the cell surface, launching a cascade of complex biochemical reactions. As a result, mucous cells begin to produce more reduced viscosity.

In addition to the above effects, bromgexine leads to the acceleration of maturation of alveolocytes - cells located in alveoli lungs and producing a specific secret called a surfactant. The surfactant is vital for the normal breathing of any mammal, since it is responsible for the alvetol distinguishing during the breath. With its absence, the condition referred to as respiratory distress syndrome develops. It is manifested by shortness of breath, the formation of skin and mucouspons, loss of consciousness and, ultimately, the death of the patient. Therefore, Bromgexin can be appointed pregnant in the second and third trimester, however, only with the threat of premature birth. The purpose of prescribing the drug is the prevention of respiratory distress syndrome in a newborn by accelerating the ripening of alveolocytes in its lungs.

The latter, but the important property of Bromgexin is the ability to accelerate the vibrational movements of the villi, lining the epithelium of the respiratory tract. Through this, the mechanical removal of liquid wet from the bronchial tresh occurs, in connection with which it accumulates in the upper airways and annoys the cough receptors. As a result, the cough is cut, becomes productive ( expectantly Mocrota) and less painful.

Due to the fact that the metabolization of the drug is carried out by the liver, and the excavation of kidneys, data from these organs can lead to the accumulation of the drug in the body and, ultimately, to its overdose. For this reason, patients with chronic liver failure and renal failure is important to adjust the dose based on the function of the above authorities. The functionality of the liver is checked by means of such analyzes as the level of promcrin, fibrinogen, bilirubin, etc. The functionality of the kidneys is estimated by determining the clearance of creatinine.

What pathologies are assigned?

Bromgexine is shown in diseases of the bronchology system, accompanied by the formation of viscous sputum. Such diseases are acute and chronic bronchitis, pneumonia, bronchiectatic disease, bronchial asthma, chronic obstructive disease of the lungs, fibrosis, tuberculosis, silicosis, etc. Also in some countries of the world, the use of bromgexine and its analogues to prevent the prevention of newborns syndrome is also practiced.

Application Bromgexina

Name of the disease	Mechanism of therapeutic action	Dosage preparation
*Acute and chronic bronchitis*	Bromgexine affects the mucous cells of the respiratory epithelium, leading to the release of by less viscous sputum in more. The drug reduces the viscosity of the mucus itself by simplifying the structure of mucopolysaccharides included in its composition. In addition, Bromgexin increases the frequency of the vibrational movements of the dies of the respiratory epithelium, which results in the acceleration of sputum from bronchi. The drug can be used to prevent newborns syndrome, but in practice, the metabolite of bromgexin - ambroxol is often used.	*Adults and children over 14 years old* the drug is shown at a dose of 8 - 14 mg 3 - 4 times a day. *Children from 6 to 14 years old and patients with weight of less than 50 kg* the drug is prescribed 8 mg 3 times a day.
*Pneumonia*
*Bronchiectatic lung disease*
*Bronchial asthma*
*Chronic obstructive pulmonary disease*
*Tuberculosis*
*Silicosis*
*Mukobovysidosis*		Due to the need for daily reception of the drug, it is imperative to choose the optimal dose that causes the necessary effect and does not complicate by the on-board reactions. Thus, the average doses of the drug are prescribed first, which are gradually decreasing to the level on which their effect is maintained, and the adverse reactions are minimal.

How to apply medication?

Bromgexine is accepted simultaneously with meals or after meals. The multiplicity of reception and dose must correspond to the age of the patient and the severity of its disease.

Adults and children over 14 years old Bromgexine is prescribed mainly in the form of a tablet and dragee 3 - 4 times a day at 8 - 16 mg.

Children from 6 to 14 years The drug is shown in the form of syrups containing in one dose of 8 mg 3 times a day.

The reception of bromgexine should be accompanied by an increase in the daily fluid consumption due to the fact that the drug accelerates its elimination through the lungs. In the presence of a patient chronic renal or liver failure, the dose of the drug must be reduced or increased the interval between its receptions in order to avoid overdose.

Possible side effects

Bromgexine can cause the following side effects:

allergic reactions;
disorders from the gastrointestinal tract;
violations by the central nervous system;
the remaining adverse reactions.

Allergic reactions

Allergic reactions are a manifestation of a hypertrophied response of the body when contact with a substance that is absolutely harmless and normally never causes tissue damage. Signs of allergies never develop in the first contact of the body with an allergen, since specific antibodies and immune cells are needed for the development of immune aggression, sensitized against allergen. To create them, the body requires time, on average equal to two weeks.

Bromgexine can cause the following allergic reactions:

contact dermatitis;
sweep quinque ( angioedema swelling);

Hives
The urticaria is the most common manifestation of allergies. The cause of its development in most cases is the use of allergen with food. Subsequently, after 15 - 30 minutes on the stomach, back, thighs, buttocks, neck, the elbow of the patient appears fine-point rash, slightly released above the skin surface. The appearance of rash is often accompanied by various intensity itching. As allergy progresses, the area of \u200b\u200bthe lesion is expanding, and the elements of the rash merge and stronger protrude above the skin surface, forming blisters. The size of the blisters can be different - from 1 - 2 centimeters to 20 - 30 cm in diameter, especially on the body.

Contact dermatitis
This manifestation of the allergic reaction is characteristic of skin contact with an allergen. At the same time, an allergic rash appears in the form of blisters, as with a string, however, the contours of the lesion clearly correspond to the contact borders of the skin and allergen.

Sweet Qincke
The swelling of quinque, or angioedema edema, is a specific type of allergic reaction, often developing in response to the allergen hit on the mucous membrane of the nose or mouth. A feature of the father's swelling is the prevail of the loose connective tissue, located around the eyes and mouth, in the cheeks, lips, the urine of the ears, the scrotum, sexual lips, etc. Distinguish with acute and chronic swelling. Acute swelling is developing within a few minutes and bears a direct threat to the patient's life, as it tends to apply to voice ligaments. The swelling of the voice ligaments sharply reduces the amount of air entering into light air, up to the complete cessation of its circulation. Chronic edema develops on the same scenario, but much longer. In this case, the patient has at least 6 to 8 hours in order to seek medical attention.

Anaphylactic shock
Anaphylactic shock or anaphylaxis develops in most cases when penetrating a certain amount of allergen into the patient's blood. At the same time, a highly sensitized organism is high in the blood of a huge amount of antibodies into the blood. As a result of the antibodies, an allergen attacks, form complexes that are deposited on the inner vessels and cause local inflammation. Given the fact that the number of circulating immune complexes is huge, the inflammatory response caused by their precipitation is also pronounced. Inflammation is accompanied by the release of substances in the blood leading to the extension of vessels ( histamine, Serotonin, Bradykin, etc.), and accordingly, a decrease in blood pressure. Thus, the clinical manifestation of anaphylaxis consists in a sharp fall of blood pressure with the loss of consciousness after the allergen hit in the blood.

Violations from the gastrointestinal tract

As mentioned earlier, Bromgeksin reduces the viscosity of the secret of all the organism glands, including gastric. The mucus on the inner surface of the stomach exercises its protection against the aggressive action of hydrochloric acid contained in the gastric juice. When the mucus is discharged under the action of high doses or long-term intake of bromgexin, the gastric mucosa is rooted, accompanied by the formation of erosions and even peptic ulcers.

In addition to the above side effect, bromgexin can sometimes lead to the appearance of an irregular chair, an unpleasant taste in the mouth, heartburn, nausea, vomit, etc.

Violations by the central nervous system

Due to the fact that bromgexine is capable of penetrating the hematorecephalic barrier and directly affect the neurons of the brain, its use in certain cases can lead to a number of side effects. The probability of undesirable effects of this drug increases when receiving an excess dose, especially for a long time.

The most frequent side phenomena from the nervous system are:

pronounced weakness;
dizziness;
nausea;
paresthesia ( feeling of goosebumps);
increase body temperature ( seldom) and etc.

Other adverse reactions

The side effects included in this subgroup are partially associated with a weak dehydrating effect of bromgexine, partly with its influence on the vegetative nervous system in people with vegetual-vascular dystonia.

Among the side effects of this group are allocated:

excessive sweating;
thirst;
dryness mucous membranes;
pulse care;
reduction of blood pressure and others.

Overdose

The overdose of bromgexine threatens the development of severe complications, such as nausea, vomiting, the pallor of the skin, pronounced general weakness, the fall in blood pressure and loss of consciousness. In order to avoid overdose, the drug should take the drug exclusively to appoint a doctor at a dose prescribed by the attached instructions.

In the case of a deliberate or accidental overdose of the drug, immediately call for ambulance. Until its arrival, it is necessary to take the following measures:

If the patient is conscious, then bring it to the knee-elbow position and cause vomiting by pressing the root of the tongue. Then make a drink at least 1 liter of water ( better 2 - 2.5 liters) And repeat artificial vomiting. Continue alternately intake water and vomiting before the appearance of pure vomit. After that, you should drink activated carbon at the rate of 1 tablet per 10 kg of body weight.
If the patient is unconscious, then it is necessary to give it a horizontal position and turn the night to avoid falling back masses into the respiratory tract. Under the head lay a pillow, rolled clothes or any improvised stand and wait for the arrival of a specialized brigade.

Interaction with other drugs

Bromgexine is not recommended to be used together with drugs that overwhelm the cough center. As a result of this interaction, the resulting liquid sputum will not be cleaned and, accordingly, will accumulate in the respiratory tract, supporting the inflammatory process.

A positive effect has a joint reception of bromgexine and antibiotics of particular penicillin and cephalosporinic series, since Bromgexin increases the concentration of the latter in the lumen of the bronchi.

Approximate cost of medication

The cost of Bromgexin varies significantly depending on the region of the Russian Federation. The table below shows the average prices for the drug in pharmacies of some major cities of Russia. The difference in prices is explained by various medicine manufacturers and its shelf life ( the more time it remains before the expiration date, the more expensive the drug).

City	The average cost of the drug
City	Tablets for adults	Tablets for children	Dragee.	Ingestion	Syrup
*Moscow*	30 rubles	48 rubles	30 rubles	127 rubles	116 rubles
*Kazan.*	42 rubles	42 rubles	98 rubles	71 ruble	120 rubles
*Krasnoyarsk*	28 rubles	28 rubles	75 rubles	75 rubles	98 rubles
*Khabarovsk*	40 rubles	40 rubles	74 rubles	87 rubles	109 rubles
*Samara*	26 rubles	26 rubles	74 rubles	80 rubles	108 rubles
*Stavropol.*	45 rubles	45 rubles	74 rubles	78 rubles	96 rubles

Name:

Bromhexin (Bromhexin)

Pharmacological
act:

Mulitatic remedy with expectorant action.
Reduces the viscosity of the bronchial secret due to depolarization of acid polysaccharides contained in it and stimulation of secretory cells of the bronchic mucosa, producing a secret containing neutral polysaccharides.
It is believed that Bromhexin contributes to the formation of a surfactant.

Pharmacokinetics
Bromgexin is quickly absorbed from the gastrointestinal tract and is subjected to intense metabolism at the "first passage" through the liver. Bioavailability is about 20%. In healthy patients, Cmax in plasma is determined after 1 h.
Widely distributed in the tissues of the body. About 85-90% is displayed with urine mainly in the form of metabolites. Metabolite Bromgexine is ambroxol.
Bromgexine binding with plasma proteins is high. T1 / 2 in the terminal phase is about 12 hours.
Bromgexin penetrates over the BC. In small quantities penetrates through a placental barrier.
Only small amounts are displayed with urine with T1 / 2 6.5 h.
Clien bromgexine or its metabolites can decrease in patients with severe disorders of the liver and kidney function.

Indications K.
application:

Bronchopulmonary diseases accompanied by the formation of high viscosity sputum:
- bronchial asthma;
- fibrosis;
- pulmonary tuberculosis;
- pneumonia;
- tracheobronchitis;
- obstructive bronchitis;
- bronchiectases;
- lung emphysema;
- Pneumoconiosis.

Mode of application:

Take Bromgexin inside (regardless of the reception of writing) in the form of tablets.
Doses for adults - 0.016 g (16 mg \u003d 2 tablets of 0.008 mg) 3-4 times a day; For children from 3 to 4 years - 0.002 g (2 mg), from 5 to 14 years - at 0.004 g (4 mg) 3 times a day; Children under 3 years old do not prescribe the drug.
The effect of the drug is beginning to manifest itself after 24-48 hours after the start of treatment. Course treatment - from 4 days to 4 weeks.

Inhalation You should dilute with distilled water 1: 1 and heat up to the body temperature to prevent cough. In patients with bronchial asthma or asmatics bronchitis, a bronchology should be taken before inhalation (the means expanding the lumen of the bronchi). Inhalation is carried out twice a day with adults 4 ml, children over 10 years old - 2 ml, children aged from 6 to 10 years - 1 ml, children aged 2 to years - 10 drops and children under 2 years old - by 5 drops on inhalation.
Parenteral (bypassing the digestive tract) introduction The drug is recommended for treatment in severe cases, as well as in the postoperative period to prevent the accumulation of thick sputum in bronchi. 1 ampoule is injected subcutaneously, intramuscularly or intravenously 2-3 times a day slowly for 2-3 minutes.
Intravenously The drug is injected together with glucose or saline.
The drug is incompatible with alkaline solutions.
If necessary, bromtexine is prescribed simultaneously with antibacterial, bronchorasmid, heart and other means.

In the process of treatment, it is recommended to use a sufficient amount of fluid that supports the secretolithic effect of bromgexine.
In children, treatment should be combined with postural drainage or vibration massage of the chest, facilitating the evacuation of the secret of the bronchi.

Side effects:

From the digestive system: Dyspeptic phenomena, transient increase in the activity of hepatic transaminases in serum.
From the CNS: Headache, dizziness.
Dermatological reactions: Increased sweating, skin rash.
From the respiratory system: cough, bronchospasm.

Contraindications:

Age up to 3 years;
- I trimester of pregnancy;
- Increased sensitivity to bromgexine.

For ulcer of the stomach, as well as in the instructions on gastric bleeding, bromgexine history should be applied under the control of the doctor.
Carefully Apply in patients suffering from bronchial asthma.

Interaction
other medicinal
means:

Bromgexin can be prescribed in combination with bronchodulators, antibacterial drugs, means used in cardiology, and other drugs.
Incompatible with alkaline solutions.
Bromgexine does not apply simultaneously with medicines containing codeine, because This makes it difficult to dig a diluted sputum.
It is used in the composition of combined preparations of vegetable origin with essential oils (including with eucalyptus oil, anise butter, peppermint oil, menthol).

Pregnancy:

When pregnancy and lactation, bromgexine is used in cases where the intended benefit for the mother exceeds the potential risk to the fetus or child.

Overdose:

Symptoms: Strengthening side reactions.
Treatment: Artificial vomiting, receiving fluid (milk or water) in the first 1-2 hours after reception, symptomatic therapy.

Release form:

1 Tablet Bromgexin Contains:
- active substance: bromgexin hydrochloride - 8 mg;
- Auxiliary substances: sugar, lactose monohydrate, starch potato, stearic acid, microcrystalline cellulose.

IN 5 ml of syrup bromgexin Contains:
- active ingredient: bromgexin hydrochloride - 4 mg;
- auxiliary substances: propylene glycol - 1250.0 mg, sorbitol (sorbitol) - 2000.0 mg, succinic acid - 12.5 mg, eucalyptus of rutoid leaves oil (eucalyptus oil) - 0.75 mg, sodium benzoate - 2.5 mg , Apricot flavor - 5.0 mg, water (purified water) - up to 5 ml.

In pathologies of the respiratory tract, the symptom of which is cough, doctors are often prescribed bromgexine. Although for children it is more convenient to use such a drug in syrup or in the form of a solution, but bromgexin is also released in tablets. How old are their use, in which dosage gives tableted bromgexin children and what other medicines can replace it?

Manufacturers and release form

The tableted form of bromgexine is produced:

Latvian manufacturer Grindex. Such bromhexine is designed for children, therefore it is represented by a dosage of 4 mg in one tablet. One pack of this medicine contains 50 tablets.

Russian producers of Farkhimfarm, biosynthesis, pharmustandart-lexing, update, atoll, iodillia-farm, Medisorb, Uralbiofarm. All these companies produce bromgexine tablets, each of which has 8 mg of active compound. One pack may contain from 10 to 50 tablets.

Domestic manufacturer Akrichin. In the assortment of drugs of such a company, there is both tablets with 8 mg bromgexin and the drug for children (tablets containing 4 mg of the active ingredient). One pack of such bromgexin may include from 10 to 100 tablets.

Berlin Hemi from Germany. This manufacturer offers bromgexin in the form of yellow-green routing, containing 8 mg of active compound.

Structure

Providing the therapeutic effect of bromgexine tablets with a compound is a bromgexine hydrochloride. Additional components of the drug are lactose, starch, wax, sucrose, silicon dioxide and other connections that should be specified in annotations to the selected medicine.

Operating principle

Bromgexine belongs to drugs with a flucolytic effect, since its main component dilutes mucoprotein and mucopolysaccharide fibers in sputum.

As a result of this action of bromgexin, the viscosity of sputum decreases, and its volume increases. This causes an expectorant effect of the drug, thanks to which the medication helps get rid of cough.

Also, Bromgexine note the ability to improve the formation of a surfactant.

Indications

Instructions for the use of bromgexin tablets recommends giving such a medicine for diseases of the respiratory tract, if the secret of the patient's bronchi is unnecessarily viscous and cleared with great difficulty. The medicine is used in bronchitis, inflammation of the lung, the appearance of bronchiectasis, asthma, tuberculosis. Also, bromgexine is prescribed in cycling.

From what age is allowed to take

Brogmexin in tablets designed for children do not recommend using before 3 years of age.

If you need to give a drug to a child up to 3 years old, a liquid form of bromgexin (solution / syrup) is used in treatment (solution / syrup), allowed from the application under the control of pediatrician from birth. Tablets in which the content of the active ingredient is 8 mg, do not prescribe for children under 6 years.

Contraindications

Tableted bromgexine can not be used in children with hypersensitivity to any of the components of the drug. Also, such a medicine is contraindicated with ulcerative lesion of the gastrointestinal tract in the aggravation stage. Special caution from the pediatrician requires the appointment of bromgexine to children with kidney diseases or liver diseases, as well as with bronchial asthma.

Side effects

For the use of Bromgexin, the children's body can "answer":

Dyspepsia.
Dizziness.
Skin rash.
An increase in liver enzymes.
Headache.
Increased selection of sweat.
Bronchospasm.

If such symptoms arose during the treatment period, the drug is recommended to cancel.

Instructions for use

Take tablet bromgexine three times a day. You can drink medicine before meals, and after it. The duration of treatment is determined for each child individually, but the boundary periods are 4-28 days.

The one-time dose of the drug depends on the age of a small patient:

For 3-5 years, they give 1 children's tablet containing 4 mg bromgexin.
At the age of 6 years old, a single dose of the drug will either 2 children's pills, or 1 tablet with 8 mg of active compound.

If necessary, the dosage may increase by a doctor to 16 mg per one app.

Instructions for bromgencency from Berlin Hemi:

Overdose

If you exceed the dose of bromgexine, it will lead to the appearance of nausea and other negative symptoms from the digestive tract. When an overdose is detected within one or two hours after receiving an excess tablet, it is recommended to provoke vomiting, after which a lot of fluid gave a child.

Interaction with other drugs

Bromgexine is successfully combined with antibiotics, bronchorants and many other medicines used in diseases of the respiratory system. It is not recommended only to combine this drug with antitussive means, because the inhibition of cough reflex with the simultaneous diffusion of sputum can provoke stagnation and deterioration of the patient's condition.

Terms of sale

Storage conditions and shelf life

Keep bromgexine in tablets at home you need in a dry place where the sunlight does not fall. It is important that the pills cannot be reached by a small child. Storage temperature should not be higher than +25 degrees. The shelf life is different from different companies and can be both 2 years or 3 years and 5 years or more.

This article allows you to familiarize yourself with the instructions for the use of the drug. Bromgexin. Reviews of site visitors - consumers of this medicine are presented, as well as the opinions of medical professionals on the use of bromgexine in their practice. A big request to more actively add your reviews about the preparation: helped or did not help the medicine to get rid of the disease, which complications were observed and side effects, possibly not stated by the manufacturer in annotations. Analogs of Bromgexin in the presence of available structural analogs. Use for cough treatment, including dry with bronchitis and asthma in adults, children, as well as during pregnancy and breastfeeding.

What kind of medicine

Bromgexine - a medicinal preparation of widespread use produced in various forms used as an effective means in the treatment of diseases and respiratory lesions, characterized by a dry irritant, wet cough with a complex composed of sputum. The substances contained in bromgexine, due to their activity, have softening, expectorant, mercolytic and even anti-inflammatory effects. Therefore, this medicine is considered to be the best preparation in the treatment of bronchitis, tracheitis, laryngitis.

It is used as an additional means with sharp pneumonia, tracheobronchites.

Bromgexin contributes to a rapid decrease in the viscosity of the resulting sputum, which gives a quick effective expectorant effect, facilitating the wet wet from the lungs. The drug is not considered toxic for the body, does not affect blood circulation. Suitable for the treatment of children, elderly people, pregnant women. Compatible with many drugs, has little contraindications.

Group of preparation

International and non-proprietary name or MNN - Bromgeksin.

Title on Latin - Bromhexinum.

A group of drugs - musolithic agents.

Trade names: Bromgraxin, Bronchotyl, Solvin, Bronarchosan, Flegamine, Flexoxin, Bromgexin 8, Bromgexin 4 Berlin Hemi.

Structure

The core of the drug constitutes its main active component - bromgexine (Bromgexin hydrochloride).

Auxiliary components: starch, gelatin, magnesium stearate, lactose monohydrate, silicon dioxide.

Depending on the form, the composition contains sucrose, calcium carbonate, magnesium, talc, glucose syrup, e-171, y-104.

Mechanism of action and properties

Pharmacology of the drug Bromgexine is determined by the following features: it is well manifesting a mercolitic, expectorant action. Its effectiveness consists in depolymerization, solving mucoprotein, mucopolysaccharide sputum fibers. An important characteristic is the ability to activate the synthesis of surfactant - the active substance generated in the cells of the lungs alveoli. The synthesis of this substance may be disturbed with all diseases of the bronchopulmonary system, which is manifested in violation of the stability of cells, weakening their reaction to harmful factors.

The drug also has some antitussive effect. Due to the effects of bromgexine, the dense wet becomes liquid, it is easier to flip out, as a result of which the cough becomes less.

Pharmacokinetics. After oral (through the mouth) of the reception, the medicine is completely absorbed in the stomach and intestines, stands out with urine. Active metabolite is an ambroxol - a substance similar to the body in the body for bromgexine. The bioavailability of the drug is about 80%.

How much does Bromgexin begin to act? The drug is perfectly absorbed, characterized by an increased adsorption capacity when using any form: syrup, tablets or inhalation form. The action manifests itself through one day after the start of the drug intake. And the pronounced therapeutic effect can be seen in two days. The maximum concentration in the patient's blood, the maximum effect is achieved an hour after use.

When and how does the drug be deducted? The half-life of the drug is 4-5 hours. Metabolism (decay) occurs in the liver. Excreted by the kidneys. The drug does not have a visible effect on the liver, but with enough long-term reception can accumulate. Bromgexin penetrates well through the hematorencephalic, placental barriers of a pregnant woman, is found in milk with breastfeeding. Along with urine, a small part of the drug is distinguished in a constant form, without affecting the kidneys.

Indications

What is needed, from which bromgexine helps?

The drug is used in the occurrence of sharp, chronic diseases of different respiratory organs, which are manifested by a dry protracted, irritating or wet cough with the formation of dense sputum. The benefits of bromgexine lies in its anti-flame properties.

What treats bromgexine?

The drug is effective in treating diseases:

Acute inflammatory diseases of the trachea, lungs, bronchi.
Faringit, Larygitis, tracheitis.
Tracheobronchites, obstructive, sharp bronchitis.
Asthma bronchial with the presence of a viscous sputum, its difficult disintegration.
infectious diseases complicated by the appearance of tracheitis, bronchitis, alveolitis.
Nosephorgitis, laryngotrachite.
Chronic bronchitis (with visible respiratory failure or its absence).
Mukobovysidosis, lung emphysema, pneumonia, tuberculosis, obstructive disease.
Congenital pathology of respiratory organs.
Bronchiectatic disease.

Why prescribe the drug in the previous postoperative period?

It can be used to clean the bronchi in the preoperative period, to prevent the accumulation of thick sputum after the operation. It is assigned to accelerate the separation of the active substance after the bronchography procedure.

Forms of release

Bromgexine can be sold in several dosage forms:

Tablets 8 or 16 milligrams.
Dragee 4, 8.12 milligrams.
Syrup, medicine of 0.0008 in 1 millilitress, is used for young children.
A solution for oral administration (through the mouth) of 2 milligrams per milliliter.
Elixir, inhalation solution, mortar for parenteral use (injections).
Solution for injection (bromgexine EGIS).

What is better: pills or capsules, injections or syrup?

The choice of drugs of the drug is made on the recommendation of the doctor depends on the shape, features of the disease, the degree of acute, age and state of the patient, other factors.

Instructions for use

How to take or prick Bromgeksin?

Before use, it is necessary to study the annotation (instruction), and it is better to consult with the attending physician.

The drug in tablets can be taken regardless of the time of meals.

Normal dosage for adults - 16 milligrams, 3-4 reception per day.

Dosage for children:

Children 3 - 4 years old rate of reception - 2 milligrams, 3 times a day.
Children after 4 years - 4 milligrams, 3 times a day.
Previously 3 years old form is not appointed.

The course of treatment varies in the interval from several days to weeks. In some diseases, in particular, with a stomach ulcer, the drug is accepted under strict medical supervision.

The inhalation solution of the drug is mixed with distilled water in equal shares, heats up to the body temperature. The procedure itself is inhalation produced no more than two times a day; Adults - 4 milliliters, children after 10 years - 2 milliliters, children from 6 years old - 1 milliliter, from 2 years - 10 drops, up to 2 years - 5 drops.

The administration of the drug parenterally through Ukolov is used in severe launched cases, in the postoperative rehabilitation period. Enter intramuscularly, subcutaneously can be several times a day 1 ampoule. When intravenous use, glucose is used, saline.

In severe cases, the maximum daily dose increases on the recommendations of medical professionals.

Side effect

The drug is perfectly transferred. Small allergic reactions (rash, rhinitis, skin itching, urticaria) are possible. The stomach and intestines can occur, there is a slightly elevated content of some enzymes in the blood, with the further use of the drug, their quantity is reduced.

With long-term reception, nausea, digestive disorders, increased ulcerative disease, dizziness, pain can appear. Rare phenomenon is an allergic swelling of quinque.

Contraindications

Absolute contraindications for reception are absent. Its use is undesirable with an increased sensitivity of the body to it, with a stomach ulcer, intestines, the availability of internal bleeding. Medication is not recommended at the initial stage of pregnancy, when feeding with breast milk. Caution is used by bromgexin in the treatment of childhood diseases, as well as diseases associated with hepatic, renal failure.

Application in children

Bromgexine for children is more often used in the form of a syrup. The drug can be with various tastes: apricot, pear, cherry.

Most of the forms can be given to children only from 2-3 years, strictly observing the above dosage standards.

The medicine is applied from birth. The dosage of the medicine determines the pediatrician exclusively.

The treatment is better to spend together with postural drainage, massage in the child of the chest, increasing the salvation of sputum.

Application in pregnancy and breastfeeding

The use of bromgexin during pregnancy, during the lactation of absolute contraindications does not have, but it is defined to coordinate with doctors. When pregnancy bromgexine is used in cases where the benefits of the mother significantly exceeds the risk to the health of the fetus. To engage in self-medication, determine the dosage "on the eye" during pregnancy, feeding is strictly prohibited. It threatens with possible serious consequences. The safest period for use is the third semester.

Application in the elderly

For persons of the old retirement age, Bromgeksin is used in the treatment of diseases and eliminate their symptoms as an expectorant. Pensioners in connection with the age impairment of the removal of metabolic products due to diseases or reducing the working functions of the liver, the kidneys is recommended to increase the usual interval between the use of the drug. The use of the drug should be under control.

Driving a car and other mechanisms

According to the instructions, it is necessary to comply with some extent caution when driving vehicles, with other hazardous activities requiring attention, reactions. Despite caution during long-term reception, the reaction remains at a high level and drowsiness does not appear.

Does the recipe need?

The drug in different forms is released without a recipe.

Compatibility with other medicines

Bromgexine has good medicinal interactions with other drugs and is prescribed along with bright-tontators, antibacterial agents, other drugs. Incompatible with alkaline nature solutions.

It is not recommended to use together with the means for blocking the cough reflex (Codelak, Stoptussin, Liebeksin), which are assigned in the presence of dry cough. There is a danger of long stagnation of sputum arises, which leads to the reproduction of harmful infectious pathogens, strengthening the process of inflammation, damage to the bronchi.

Compatible with alcohol

Taking bromgexin with alcohol is prohibited categorically. To avoid consequences, it is necessary to abandon all alcohol for the period of treatment. With a periodic compatibility violation, the drug may strengthen its side effects on the liver, the likelihood of development of ulcers will appear. Headache appears, noise in the ears, total lethargy. With a launched state, the combination of alcohol and a medical device leads to the ulceration of the stomach shell, the occurrence of internal bleeding.

Analogs of the drug Bromgeksin

Structural analogues for the acting substance:

Bromgexin 4 Berlin Hemi;
Bromgexine 4 mg for;
Bromgexin 8;
Bromgexin 8 Berlin Hemi;
Bromgexine 8 mg;
Bromgexin Grindex;
Bromgexin MS;
Bromgexin Nicomed;
Bromgexin acry;
Bromgexin Ratiopharm;
Bromgexin RusFar;
Bromgexin UFF;
Bromgexin Ferain;
Bromgexin Egis;
Bromgexine hydrochloride;
Bronchotyl;
Faith-bromgexine;
Solvin;
Flagamine;
Flexone.

In the absence of analogues of drugs on the active substance, you can follow the links below on the disease, which helps the appropriate drug, and see the analogues on therapeutic effects.

LP-004535-131117

Trade name of the drug:

Bromgexin

International non-proprietary name:

Bromgexin

Dosage form:

Tablets for children

Structure:

1 tablet:
active substance: Bromgexine hydrochloride - 4.00 mg.
Excipients: lactose monohydrate (milk sugar) - 80.23 mg; Corn starch - 11.54 mg; Povidone K-25 - 3.46 mg; Magnesium stearate - 0.77 mg.

Description:

Round plascondrical tablets of white or almost white color with faceted and risky.

Pharmacotherapeutic Group:

expectorant Mulitics.

ATH code:

R05CB02.

Pharmacological properties

Pharmacodynamics
Multic (secregolytic) remedy, has an expectorant and weak antitussive effect. Reduces the viscosity of sputum (depolymerizes mucoprotein and mucopolysaccharide fibers, increases the serous component of the bronchial secret); Activates the fixed epithelium, increases the volume and improves the detection of sputum.
Stimulates the production of endogenous surfactant, ensuring the stability of alveolar cells during the respiratory process. The effect is manifested in 2-5 days from the start of treatment.

Pharmacokinetics
When taking inside, bromgexine almost completely (99%) is absorbed into the gastrointestinal tract for 30 minutes. Bioavailability - low (the effect of primary "passing" through the liver). Bromgexine in a plasma is associated with proteins, penetrates the hematorecephalic and placental barriers, as well as in breast milk. In the liver, bromgexine is subjected to demethylation and oxidation, metabolized to pharmacologically active ambroxol. Half-life (T½) -15 h (due to slow reverse diffusion from tissues). Excreted by the kidneys. In chronic renal failure, bromgexine metabolites are disturbed. With repeated use, bromgexin may be cumulated.

Indications for use

Acute and chronic bronchopulmonary diseases accompanied by the difficulty of extracting viscous sputum: tracheobronchitis, bronchitis of different etiology (incl. Complicated by bronchiectasses), bronchial asthma, pulmonary tuberculosis, lung emphysema, pneumonia (acute and chronic), pneumoconiosis, fibrousosis.
The reservation of the bronchial tree in the preoperative period and when conducting therapeutic and diagnostic intrabrochetic manipulations, the prevention of the accumulation in bronchi thick viscous sputum after the operation.

Contraindications

Increased sensitivity to the components of the drug, ulcerative ulcer of the stomach and 12-rosewood, pregnancy, period of breastfeeding, child age up to 3 years, hereditary lactose intolerance, glucose-galactose malabsorption, lactase deficiency.
Carefully
Apply in patients with gastric bleeding in history, with diseases of the bronchi, accompanied by the excessive accumulation of the secret, if there is a history of hemopodes, renal and / or hepatic insufficiency.

Application during pregnancy and in breastfeeding period

Bromgexine penetrates through a placental barrier, as well as in breast milk. The drug is contraindicated to use during pregnancy and during breastfeeding period.
If necessary, the use of the drug during the lactation during treatment should be stopped breastfeeding.

Method of application and dose

Inside, regardless of meals.
Children over 10 years old: 24-48 mg (6-12 Tab.) divided into 3 receptions per day (daily dose - 24-48 mg bromgexine).
Children from 6 to 10 years old, as well as patients with a body weight of less than 50 kg - 12-24 mg (3-6 tab.) divided into 3 receptions per day (daily dose - 12-24 mg bromgexin).
Children from 3 to 6 years old - 6-12 mg (11/2 -3 tab.), divided into 3 receptions per day (daily dose - 6-12 mg of bromgexine).
Therapeutic action can manifest itself on the 4-6 day of treatment.
Course of treatment from 4 to 28 days.
Patients with renal failure are prescribed smaller doses or increase the interval between the receptions.

Side effect

From the gastrointestinal tract: abdominal pain, dyspepsia, incl. Nausea, vomiting, aggravation of ulcerative disease of the stomach and a 12-rosewoman.
Allergic reactions: Hypersensitivity reactions (skin rash, itching, angioedema edema, rhinitis), urticaria, fever, anaphylactic reactions, including anaphylactic shock.
From the side of the skin and subcutaneous fabrics: Stevens-Johnson Syndrome, Layella Syndrome, acute generalized Springatous Pustulose.
Others: dizziness, headache, increasing the activity of "liver" transaminase in serum.

Overdose

The following symptoms are possible: nausea, vomiting, diarrhea and other gastrointestinal disorders.
Treatment: Specific antidote no. When overdose, it is necessary to cause vomiting, and then the patient gives fluid (milk or water). Stomach washing is recommended for 1-2 hours after taking the drug.

Interaction with other medicines

Bromgexine is not prescribed simultaneously with drugs overwhelming the cough center (including codeine containing), since it makes it difficult to deprive the discharge of sputum (accumulation of bronchial secrets in the respiratory tract).
Bromgexin contributes to the penetration of antibiotics (amoxicillin, ampicillin, erythromycin, cephalexin, oxytetracycline), sulfonamide drugs in the bronchial secret in the first 4-5 days of antimicrobial therapy. The joint use of bromgexin with some non-steroidal anti-inflammatory drugs (salicylates, phenylbutasone or butadion) may cause irritation of the gastric mucosa.

special instructions

It was very rarely reported on the occurrence of Stevens-Johnson and Layella syndromes, which are in temporary connection with the reception of Bromhexin. In the event of changes on the skin or mucous membrane, it is necessary to stop taking the drug and consult a doctor.
In the process of treatment, it is recommended to use a sufficient amount of fluid that supports the secretolithic effect of bromgexine.
In children, treatment should be combined with postural drainage or vibration massage of the chest, facilitating the evacuation of the secret of the bronchi.

Impact on the ability to manage motor vehicles and working with mechanisms

Receiving recommended therapeutic doses (16 mg 3 times a day) does not affect the rate of psychomotor patient reactions. In the case of the development of side effects when applying the drug, caution should be taken when driven by vehicles and mechanisms.

Form release

Tablets for children 4 mg.
10, 20, 25, 30, 40, or 50 tablets into the contour cellular packaging from the film of polyvinyl chloride and foil aluminum printed lacquered.
10, 20, 30, 40, 50, or 100 tablets into polyethylene terephthalate banks or polypropylene for drugs, clapped with high-pressure polyethylene covers with the control of the first opening or to the "Press-rotate" system or lids from low pressure polyethylene with the first-pressure control. Opening.
One bank or 1, 2, 3, 4, 5 or 10 contour cellular packages along with the application instructions are placed in cardboard packaging (pack).

Storage conditions

In the place protected from light at a temperature not higher than 25 ° C.
Keep out of the reach of children.

Shelf life

3 years. Do not apply after the expiration date.

Conditions of vacation

Release without a recipe.

Manufacturer

LLC "OZON"

Legal address:
445351, Russia, Samara region, Zhigulevsk, ul. Sandy, d. 11.

Production address, including for correspondence and acceptance of claims:
445351, Russia,
Samara region, Zhigulevsk, ul. Hydrostrolers, d. 6.