Eufillin for injection instructions for use. Eufillin: Instructions for use in ampoules, readings and reviews. Side reactions and overdose

- means of a phosphodiesterase inhibitor. It helps to reduce calcium ions and, as a result, reducing the contractile ability of smooth muscles. Mostly the drug is used as an armor-taircuit, a vasodilator, a diuretic.

The composition of the drug

The main active substance is Aminofillin. It is he who provides all pharmacological actions that will be described below.

If the drug in ampoules, then injecting water is contained together with aminoophylline. If it is a tablet form, then the composition will include pose, magnesium stearate, potato starch.

Pharmacological group - adenosine-corporal substances.

Mechanism of action

By blocking phosphodiesterase, reduces the concentration of CA ions. Low calcium levels weakens the reduction capacity of the smooth muscles. All this is manifested by the relaxation of muscles: bronchi, vessels; He will stop bronchospasm, the operation of respiratory muscles is improved. The filling of blood oxygen is enhanced, the frequency of apnea attacks is reduced, the respiratory center is stimulated.

Acting for vessel receptors, reduces their tone, contributing to expansion. Increases blood flow in the kidneys, because of which the removal of urine is accelerated, and therefore diuresis. Improves blood flow in cardiac arteries, reinforcing the frequency and strength of heart abbreviations.

Acting on the cells of the immune system (fat cells) reduces the emission of substances causing inflammation, thereby reducing allergic manifestations.

Release form:

Eufilline is produced and sold in powders, tablets or solutions in ampoules. Powder in bags is used extremely rare.

In the form of tablets: 1 tablet contains 0.15 g substances. In the blister usually 10 tablets, and in the package 3 blisters.

Another form is a solution in ampoules 12% 2 ml. Such a dose is universal both for subcutaneous and intravenous and intramuscular injections. Ampoules with 2.4% in 10 ml is used purely with the introduction of injections intravenously.

Store Eufillin need at a temperature of 25 degrees and less.

Analogs

If bright side effects from Euphilline are developing or there is no means in free access, it is possible to replace it with groups of drugs with a similar effect:

• Teotard in capsules of 200, 250, 300 mg;
• Eufillin-UFB in 150 mg tablets;
• Theophyllin-200 in tablets of 200 mg;
• Theophyllin-300 in 300mg tablets;
• Teopek in tablets of 100, 200, 300 mg;
• COMBIPEK in tablets 6 mg + 200 mg;
• Neophyllin in 100 mg tablets and 300 mg.

It is impossible to cancel the appointed tool independently and it is impossible to replace it, despite the fact that these properties are similar. Only a specialist is capable of replacing the tool, since only he can take into account all the side effects and the risk of their development in a particular patient.

Indications for use

From what the drug helps:

• Asthmatic status;
• Apnea;
• Violation of cerebral circulation;
• Swelling with renal cause;

Some women prefer to use Eufillin to combat cellulite by adding it to their moisturizing or anti-cellulite cream.

But so far there are no reliable sources conducted research on the effect of medication to eliminate cellulite, so it is impossible to talk about efficiency. As such harm, such a method of application will not bring if there is no allergies to the substance.

Contraindications

1. individual hypersensitivity;
2. increased or vice versa reduced pressure;
3. myocardial infarction in the past, the present violation of the heart rhythm;
4. hereditary disease - hypertrophic cardiomyopathy;
5. epilepsy;
6. pulmonary edema;
7. deficiency on the side of the kidneys and liver;
8. stroke (especially hemorrhagic);
9. pregnancy and lactation period. The properties of the euphilline include the ability to pass through the placenta shells into the child's body, creating such a concentration in it, which turns out to be dangerous and even destructive. Also, the medicine falls into Mother's milk, and, again, in the child's body, which is dangerous for him.

Side effects

The main side phenomena are:

• dizziness,
• spring on the skin,
• sleep disturbance,
• the appearance of anxiety disorders,
• the appearance of convulsive syndrome and tremor,
• nausea, vomiting,
• possible small heartburn, diarrhea.

If you look from the heart of the heart, then possible:

• heart palpitations
• strengthening angina
• possible pain in the heart of the heart,
• tachycardia,
• reduced pressure.

Method of application and dose

In Tablets, Eufillin drink after meals. 1-3 times a day 1 tablet 0.15 g, for children - 4 times. The frequency of reception, duration, how much to drink the drug in days is determined only by the doctor.

If Eufillin is assigned in ampoules, then the solution is introduced 1-3 times / day intravenously, with a calculation of 10 mg / 1 kg of body weight.

How to dilute the drug in ampoules?

The frequency of administration and dose establishes the doctor. Usually, in the first injections, a small concentration of the substance is used, collecting it before using in physical pressure under pressure control, since Eufillin is able to change it. Adult 2.4% solution of 15 ml is bred in 100 ml of 0.9% sodium chloride.

It is prohibited independently to dissolve EUFILLIN without determining the dosage and concentrations of a specialist. Especially if we are talking about children.

Enter slowly. Children under 18 years old or infants a solution ratio is less and regulated by a pediatrician.

Overdose

When the dose is exceeded above the therapeutic symptoms associated with overdose. It is manifested by a decrease in appetite, nausea, vomiting, tachycardium, insomnia, anxiety.

The appearance of bleeding in the gastrointestinal tract, convulsions, epilepsy attacks are also signs of overdose. The pressure drop, deficiency from the kidneys, are also developing when the dose is exceeded.

If these symptoms developed or at least some of them, first of all, should stop taking the drug. With the appearance of vomiting - the reception of methoclopramid, seizures - oxygenotherapy, and if the epileptic attack has developed intravenously to introduce diazepams with a calculation of 0.2 mg / 1 kg of mass. Recommended forced diuresis, hemosorption.

A warning

During the use of Euphillin, it is necessary to seriously monitor its diet. It is necessary to limit the use of coffee and caffeint-containing products and drinks.

People with long experience of smoking need to increase the concentration of the injected drug, because Nicotine prevents his assimilation.

Eufillin with cervical osteochondrosis

Taking into account all the effects that medicine on a person in general, it is possible to understand such a wide prevalence of it as a means for the treatment of cervical osteochondrosis.

Showing a relaxing effect on the spashed cervical muscles, the vasodilator, it normalizes the circulation of blood and the nutrition of these muscles, which improves the power of the cartilage of the spinal cervical.

For the treatment of cervical osteochondrosis, the optimal solution is intravenous administration. In this case, the drug is better absorbed and has a greater therapeutic effect.

Electrophoresis of the cervical euphilline

For better penetration of the substance in the deep structure of the neck, electrophoresis with euphilline on the cervical spine can be used. It is applied in case of detection of hernia, osteochondrosis. Electrophoresis is effective for both infants.

What is the method of electrophoresis? Several electrodes are superimposed on the cervical department, on which there is a necessary dosage of Euphillin. A small discharge current is served. The drug applied to the electrodes is moving under the action of the electric field and penetrates into the necessary structures, in particular, the skin.

The effect of electric current has already a positive therapeutic effect, especially efficiently eliminates edema, and when combined with the introduction of Euphillin, this effect is enhanced.

A significant advantage of the introduction of euphilline with electrophoresis is that the drug does not affect other organs, but acts locally at the place of application and penetration, where its maximum concentration is created.

• Eufillin Instructions
• The composition of the preparation of Ehufillin
• Indications of the preparation of Eufillin
• Conditions for the storage of the drug Eufillin
• The shelf life of the drug Eufillin

ATX code: Respiratory system (R)\u003e Preparations for the treatment of bronchial asthma (R03)\u003e Other preparations for the treatment of bronchial asthma for systemic use (R03D)\u003e Xanthine derivatives (R03DA)\u003e Aminophylline (R03DA05)

Release form, composition and packaging

pR D / B / in administration 24 mg / ml: 5 ml of AMP. 10 pieces.
Reg. No: 19/03/566 of 05/30/2018 - Duration Reg. UD. is not limited

Introduction Solution Colorless or slightly yellowish, transparent.

Excipients: Water d / and.

5 ml - ampoules (10) - cardboard boxes.
5 ml - ampoules (10) - packs cardboard.

Description of the medicinal preparation Eufillin Rr Created in 2013 on the basis of the instructions posted on the official website of the Ministry of Health of the Republic of Belarus. Renewal date: 01/23/2014

pharmachologic effect

The effect of euphilline is due primarily to the content of theophylline in it. Ethylenediamine enhances antispasmodic (removable spasms) activity and contributes to the dissolution of the drug. An important features of the euphilline are its solubility in water and the possibility of it in / in administration. Eufillin relaxes the muscles of the bronchi, lowers the resistance of blood vessels, expands the coronary (hearty) vessels, lowers the pressure in the pulmonary artery system, increases the kidneying blood flow, has a diuretic (diuretic) action associated mainly with a decrease in the tubular reabsorption (reverse water absorption in the renal tubules), It causes an increase in removal from urine water and electrolytes, especially sodium and chlorine ions. The drug strongly slows down the aggregation (gluing) platelets.

Blocks adenosine receptors, inhibits the activity of phosphodiesterase, increases the level of cyclic AMP, reduces the level of ionized calcium in smooth muscle cells.

Indications for use

• aminophillin is a complex of theophylline and ethylenediamine and its purpose is determined by the activity of theophylline, which relaxes the smooth muscles and will be stopped by bronchospasm;
• aminoFillin for injections is shown to relieve bronchospasm associated with asthma and chronic obstructive lung disease.

Dosing mode

Amino phyllin for injection of 24 mg / ml is intended for slow to / in administration. The solution must be introduced very slowly for 4-6 minutes of 5-10 ml of the drug (0.12-0.24 g), which is pre-brutened with a small volume (5-10 ml) of 5% dextrose or 0.9% sodium chloride solution for injections.

Supporting therapy can be provided by introducing large volumes of infusion solutions, the rate of administration is regulated in such a way as to ensure the required amount of the drug every hour.

Typically, with drip administration, 10-20 ml of the drug (0.24-0.48 g) is divorced at 100-150 ml of 0.9% sodium solution of chloride and administered at a speed of 30-50 drops per minute.

Before parenteral administration, the solution must be heated to the body temperature. Parenterally introduces aminoophyllin to 3 times / day, not more than 14 days. The highest doses of aminoophylline for adults with in / in the introduction:

• one-time - 0.25 g, daily - 0.5 g.

The therapeutic concentration in the blood plasma of theophylline is considered in the range from 5 to 20 μg / ml, and the levels above 20 μg / ml are most likely associated with a toxic effect. It also notes an individual variation in each individual patient in the dosage required to achieve the concentration of theophylline in the plasma of the blood located in the desired therapeutic range.

During therapy, patients should be under careful observation for toxicity and, where possible, the content of theophylline should also be monitored, doses should be calculated on the basis of the ideal body weight, the drug is not recommended for children up to 6 month old due to significant oscillations in the monophylline metabolism in young children.

Patients who have not received theophylline preparations

A. Load dose of aminophylline 6 mg / kg body weight can be given to / in slowly at a speed not exceeding 25 mg / min.

B. Depending on the condition of the patient, the dose over the next 12 hours can be calculated as follows:

• children aged 6 months to 9 years: 1.2 mg / kg / h (decrease to 1 mg / kg / h after 12 hours);
• children aged 9 to 16 years old and young adult smokers: 1 mg / kg / h (decrease to 0.8 mg / kg / h after 12 hours);
• healthy non-smoking adults: 0.7 mg / kg / h (decrease to 0.5 mg / kg / h after 12 hours);
• elderly patients and face with a pulmonary heart: 0.6 mg / kg / h (decrease to 0.3 mg / kg / h after 12 hours);
• patients with stagnant heart failure or liver diseases: 0.5 mg / kg / h (decrease to 0.1-0.2 mg / kg / h after 12 hours);

Patients already receiving theophylline

The loading dose can be calculated on the basis that every 0.5 mg / kg of theophylline administered in the form of a load dose can lead to an increase in 1 μg / ml of the concentration of theophylline in serum.

Ideally, the introduction must be postponed before the determination of theophylline in the blood serum. If this is not possible and, if the clinical situation requires the drug to be injected, then in a dose of 3.1 mg / kg of aminoophylline (equivalent of 2.5 mg / kg of anhydrous theophylline) on the grounds that this may lead to an increase in the concentration in theophylline serum approximately 5 μg / ml when administered as a load dose.

Side effects

Aminophyllin can cause an irritation of the gastrointestinal tract, stimulation of the central nervous system and to influence the cardiovascular system. Hypotension, arrhythmia and convulsions can follow in / in injections, especially if the injection is done too quickly. Also received reports of sudden death. Heavy toxicity can occur without preceding symptoms of precursors.

The immune system: Allergic reactions.

Violations of metabolism and nutrition: Metabolic disorders, such as hypocalemia, hypophosphatemia, hyponatremia.

Mental disorders: Anxiety, insomnia. Higher doses can lead to manic behavior and delusion.

Nervous System Disorders: Headache, confusion of consciousness, anxiety, hyperventilation, dizziness and tremor. Higher doses can lead to cramps.

Outcomes of the organ of vision: Spectatical disorders.

Cardiac disorders: Heartbeat, tachycardia, heart rate disorders, arterial hypotension.

Gastrointestinal disorders: Nausea, vomiting, abdominal pain, diarrhea, gastrointestinal reflux, gastrointestinal bleeding.

Skin diseases and subcutaneous fiber: Rash, fodder-papular rash, redness, itching, urticaria, exfoliative dermatitis.

General violations: Inject injections are painful, the pain lasts a few hours. Higher doses can lead to hyperthermia and thirst.

Contraindications for use

• amino phyllin for injections should not be used in patients with increased sensitivity to ethylene diamine or with allergies on theophylline, caffeine and theobromin;
• aminophyllin should not be prescribed simultaneously with other xanthertine-containing drugs. When prescribing the therapeutic doses of euphilline and / or theophylline at a time more than one way of administration or more than one drug, the risk of serious toxicity increases;
• the use of aminoophylline V / B in children under the age of 6 months is usually not recommended;
• the use of aminoophylline is contraindicated in patients with acute porphyria.

Application in pregnancy and breastfeeding

Studies of influence on the reproductive function in animals were not fulfilled with theophylline. Can theophylline can cause embryonic harm when introducing pregnant women. Despite this, the safe use of theophylline during pregnancy was not established regarding potential risk for the fetus, theophylline was used during pregnancy without teratogenic or other negative effect on the fetus. In connection with the risk of uncontrolled bronchial asthma, security during pregnancy, when the introduction of aminoophylline is really necessary, as a rule, is not questioned. The question of using aminoophylline during pregnancy is a doctor. Theophyllin penetrates the placenta.

Theophylline is distributed into breast milk and can sometimes cause irritation or other signs of toxicity in infants and, therefore, should not be used with nursing mothers.

special instructions

To reduce the unwanted stimulating effects of euphilline to the central nervous and cardiovascular system, the introduction of the drug must be slow and the speed should not exceed 25 mg / min.

Aminofillin has a narrow therapeutic index and serum concentration should be monitored regularly, especially during the start of therapy.

AminoFillin for injections should be administered carefully in patients over 55 years.

In elderly patients, with heart or hepatic disease, the presence of signs of toxicity of theophylline should be carefully monitored.

Children are especially susceptible to theophylline effects and care is required when appointing aminoophylline in children.

There were reports of convulsions in children who were appointed theophylline at the concentration of the latter in the blood plasma within the framework of the adopted therapeutic range. Alternative treatment should be considered in patients with convulsive activity in history, and if the aminoophyllin for injections is used in such patients, they must be carefully examined for possible signs of CNS hyperstimulation.

Due to the fact that the average T 1/2 Theophylline is shorter than smokers than non-smoking, the first group may require large doses of Euphillin.

Care should be taken in patients undergoing influenza immunization or which have an active infection of influenza or sharp febrile diseases.

Aminophyllin should be prescribed with care patients with heart failure, chronic obstructive pulmonary disease, renal or hepatic dysfunction and in chronic alcoholism, as the clearance of aminoophylline decreases.

During regular therapy, serum levels of potassium should be monitored. This is very important when combined therapy with beta-2-agonists, corticosteroids or diuretics, or in the presence of hypoxia.

The aminoofillin should be used with caution in patients with ulcerative disease, hyperthyroidism, glaucoma, diabetes mellitus, severe hypoxhemia, arterial hypertension and heart function disorders or blood circulation, since these states can be aggravated.

Methylxantins can increase the acidity of gastric juice and the corresponding measures should be taken if they are used in patients with ulcerative disease in history.

Aminophyllin should not be prescribed simultaneously with other xanthertine-containing drugs.

There is no information about the impact on the ability to drive a car and work with the mechanisms.

Overdose

Aminofillin has a narrow therapeutic index. Theophylline toxicity is likely to occur during serum concentrations exceeding 20 μg / ml, and is becoming increasingly severe in high serum concentrations.

Doses of more than 3 g may be serious in adults (40 mg / kg in a child). A deadly dose can be only 4.5 g in adults (60 mg / kg in a child), but, as a rule, it is higher.

The death in adults can occur when the aminoophylline is introduced in large doses in patients with renal, hepatic insufficiency or with cardiovascular complications, or if the injection was made quickly.

Symptoms: Tachycardia, in the absence of hypoxia, fever, or with the joint introduction of sympathomimetic drugs, may be a sign of the toxicity of theophylline.

Gastrointestinal symptoms:anorexia, nausea, vomiting, diarrhea, vomiting with blood.

Neurological symptoms:anxiety, insomnia, irritability, headache, excitement, hallucinations, severe thirst, a slight increase in temperature, expansion of pupils and noise in the ears. Causes may occur even without preceding toxicity symptoms and often lead to death. Coma can develop in very difficult cases.

Cardiovascular symptoms:heartbeat, arrhythmia, arterial hypotension, supersparce and ventricular arrhythmia.

Metabolic symptoms:hypokalemia can develop quickly and may be serious. Hyperglycemia, albuminuria, hyperthermia, hypercalcemia, hypophosphatemia, hypercalcemia, respiratory alkalosis, metabolic acidosis and rhabdomyolysis can also occur.

Treatment: Overdose treatment is supportive and symptomatic.

Serum levels of theophylline and potassium must be checked. The re-oral administration of activated carbon contributes to the elimination of theophylline from the body, even after intravenous administration. Could require aggressive antiemetic therapy so that the oral administration of activated carbon is possible.

Clear can be stopped in / in the administration of diazepam 0.1-0.3 mg / kg to 10 mg / kg. Restoration of the balance of fluid and electrolytes is necessary. Hypokalemia must be corrected by means of potassium chloride infusion. It may be necessary for diazepam sedation in excited patients.

Propranolol can be introduced in / B for tachycardia reverse, hypokalemia and hyperglycemia, provided that the patient does not suffer from asthma.

In general, theophylline is metabolized quickly and hemodiadis is not justified. In patients with stagnant heart failure or liver diseases, hemodialysis can increase theophylline clearance by 2 times.

Hemosorption should be considered if:

• intestinal obstruction interferes with the introduction of several doses of activated carbon:
• plasma concentrations of theophylline\u003e 80 mg / l (sharp) or\u003e 60 mg / l (chronic). In the elderly, hemosorption should be considered at the concentration of theophylline\u003e 40 mg / l. Clinical signs, not the concentration of theophylline, are the best leadership for treatment.

Eufillin is a pharmacological preparation related to the group of xanthines. All dosage forms contain an active ingredient - aminoophyllin, which is a combination of theophylline and ethylenediamine.

The medicine has an expanding effect on bronchi, relaxing their smooth muscles and eliminating spasms. In addition, it improves the operation of the cilia of the respiratory tract, improves the reductions of the diaphragmal, intercostal and other respiratory muscles.

Eufillin excites vessels and respiratory centers and improves / activates blood circulation. Additionally, the drug reduces the tone of blood vessels (mainly of the vessels of the brain, leather and kidney).

Eufillin photo of tablets and ampoules (injections)

It has a peripheral ventilating effect, reduces pulmonary vascular resistance, reduces the pressure in the "small" circle circle. Increases renal blood flow, has a moderate diuretic effect.

Eufillin has a tocolic effect, due to which the acidity of the gastric juice increases. In large concentrations, an enileptogenic effect is provided.

Active substance Eufillain is theophylline. It is well and quickly absorbed from the gastrointestinal tract and has high bioavailability. Penetrates through a placental barrier in breast milk. Metabolized in the liver and is derived by renal.

Eufillain Indication Indications

• chronic obstructive bronchitis;
• bronchial asthma (prevention of bronchospasm, the drug of choice during the asthma of physical stress, additional tool, with other formats of asthma);
• lung emphysema;
• night paroxysmal apnea (Pickwick syndrome);
• chronic pulmonary heart.

Eufillin injections are prescribed intravenously with sharp attacks of bronchial asthma and strokes.

Eufillin Tablets - a means of systemic use for the treatment of obstructive respiratory diseases.

Instructions for the use of eufillin, dosage

Eufillin injeces

The intravenous injection of eufillin is introduced insert slowly, for 4-6 minutes in a dose of 0.12 - 0.24 g (5-10 ml of 2.4% solution, which is pre-bred in 10-20 ml of isotonic sodium chloride solution).

Intravenously drug is administered under the control of heart rate, respiration and blood pressure.

Eufillin injected spasmodic effect provides a pronounced anti-colic effect, increases the secretion of the pancreas, so with various diseases of the digestive organs, accompanied by excessive pancreatic insufficiency, and also if the latter arose due to chronic pancreatitis, prescribed intravenous injections of 10 ml of 2.4% solution.

The intramuscular injection is introduced in 2-3 ml of 12% of the solution of euphilline or 1-1.5 ml of a 24% solution of euphilline. It is recommended to make injections to the upper sector of the jagged muscle at a dose of 100 - 500 mg per day.

If the patient has an asthmatic status - it is prescribed the infusion administration of a medication in the amount of 720 or 750 mg.

The duration of therapy of the injection form of the drug can not be more than 14 days.

Tablets Ehufillin

Reception of the medication orally - in tablets, 0.1-0.2 g 2-3 times a day after eating.

Adults and teenagers with a body weight of more than 50 kg, depending on the clinical situation, are prescribed 150-300 mg (1-2 tablets) 3 times a day, in severe cases of 300 mg (2 tablets) 4 times a day with an interval of 6 hours. Daily dose on average 600-1200 mg or 4-8 tablets in 3-4 administration.

If it is necessary to facilitate the state of chronic obstructive diseases of the lungs in a state of exacerbation, it is recommended to begin with a dose of the drug in 5-6 mg / kg. Eutillin must take carefully, constantly controlling its amount in the blood.

The maximum daily dose in adults is 10-13 mg / kg (0.4-0.5 ml / kg), in children aged 6-17 years - 13 mg / kg body weight (0.5 ml / kg), from 3 years to 6 years - 20-22 mg / kg (0.8-0.9 ml / kg).

The number of medication Eufillin, an appointed child, determines the doctor, considering the weight and age of the child, as well as the sharpness of the disease.

Features of application

The purpose of Euphillin patients with chronic heart and liver insufficiency, pneumonia or viral infection, as well as elderly patients, requires adherence to caution and reduce doses of the drug.

During treatment, Euphillin should refrain from alcohol consumption.

It should be noted that the Medicine "Eufillin" can increase the level of uric acid in Urin. During the use of this medicine, it is necessary to observe special caution while using a large number of products and beverages containing caffeine.

During the period of therapy, Euphillin needs to refrain from driving transport and occupation by other potentially hazardous activities requiring increased concentration and speed of psychomotor reactions due to possible side effects.

Side Effects and Contraindications Eufillin

Dyspeptic disorders (digestion disorders), with intravenous administration dizziness, hypotension (decrease in blood pressure), headache, migraine, heartbeat, cramps, with rectal use irritation of the mucous membrane of the rectum.

Overdose

In responses about Euphilline, it was noted that during the overdose of medication there are generalized convulsions, light-free, sleep disorders, ventricular arrhythmias, tachycardia, hyperemia of facial, tachipne, nausea, vomiting, diarrhea, anorexia. With the development of these symptoms, the drug is needed and active stimulation of its removal from the body.

Contraindications:

• heart rate violation;
• myocardial infarction;
• extrasystole;
• heart failure;
• paroxysmal tachycardia;
• coronary failure.

Intravenous introduction to children up to 14 years old is contraindicated.

During pregnancy and lactation, the use of the drug is possible only on life indications. The use of aminoophylline during pregnancy can lead to the creation of potentially hazardous concentrations of theophylline and caffeine in the plasma of the newborn blood. Newborn, whose mother in pregnancy received aminoophyllin (especially in the third trimester), requires medical observation to control the possible symptoms of theophylline intoxication.

Eufillin Analogs, List

The analogues of Eufillin include drugs (list):

1. Aminoofillin-esk;
2. Teotard;
3. Diprofillin;
4. Omnitus;
5. Berodal;
6. Tavipek;
7. Pertissin;
8. Ventoline;
9. SERELET;
10. Spiriva;
11. Fenoterol.

It is important to understand that the instructions for the use of Eufillin, the price and reviews for the analogues of the drug do not include and cannot be used as a guide for application, replacement or other actions. All therapeutic actions should be carried out by a specialist, when replacing Eufillin on analogue, a dosage correction or the entire course of treatment may be required.

Medicine Eufillin Instructions for use refers to bronchophimists with antispasmodic and vasodilatory properties. Tablets 150 mg, injections in ampoules for injection in the solution intravenously and intramuscularly prescribed for the excitation of vessels and respiratory centers, to improve blood circulation. Patient reviews and recommendations doctors report that this medicinal product helps in the therapy of asthmatic status and bronchorate.

Release form and composition

The pharmacy comes:

1. The solution for intramuscular administration is 240 mg / ml (injections in ampoules for injection).
2. A solution for intravenous administration of 24 mg / ml (injections in ampoules, in droppers).
3. Tablets 150 mg.

One tablet contains 150 mg of active substance - aminoophylline, as well as calcium stearinovascular and potato starch.

The composition of the injection solution, aminoophyllin enters in a concentration of 24 mg / ml. As auxiliary component, water d / and is used.

What helps Eufillin (pills and injections)?

Indications for the use of medication in tablets:

• chronic obstructive bronchitis (hob);
• bronchial asthma (BA);
• chronic "pulmonary heart";
• pickwick syndrome (night paroxysmal apnea);
• emphysema of the lungs.

Eufillin is a drug selection with physical voltage, with other forms of the disease, it is used in combination with other drugs.

Crosses in ampoules are prescribed in cases where the patient is diagnosed:

• migraine;
• left-deceiving deficiency, accompanied by periodic breathing type of Chein-Stokes and bronchospasm (in combination with other drugs);
• broncho-abstructive syndrome with bronchitis, ba, cardiac asthma (mainly to relieve attacks) or lung emphysema;
• hypertension in the pulmonary circulation circle;
• cerebrovascular brain failure (the solution is applied in combination with other drugs to reduce intracranial pressure).

Instructions for use

Eufillin Tablet

Take inside, adults should be prescribed 150 mg to receive 1-3 times a day after meals. Children inside should be prescribed at the rate of 7-10 mg / kg per day in 4 reception. The duration of the course of treatment is from several days to several months, depending on the course of the disease and tolerance of the drug.

Higher doses of Euphillin for adults inside: one-time - 0.5 g, daily - 1.5 g.

Higher doses for children inside: one-time - 7 mg / kg, daily - 15 mg / kg.

Injection

Individual treatment scheme, which, depending on the testimony, age, clinical situation. The solution is administered intravenously, intramuscularly, through the drip drip.

pharmachologic effect

Eufillin relaxes the smooth muscles of the bronchi and eliminates spasms, thus expanding the influence on them. In addition, it improves the functioning of the cilia of the epithelium of the respiratory tract, improves the reduction of many muscles, including intercostal and diaphragmal.

The medication is able to stimulate the respiratory center located in the oblong brain and improve the pulmonary ventilation, contributing to the saturation of the blood with oxygen and decrease the amount of carbon dioxide in it. The mechanism of the effects of euphillin on the human body is to oppress one of the enzymes - phosphodiesterase.

It helps to reduce the flow of calcium ions in the cells, which are responsible for the contraction of the muscles, relax the muscles of the bronchi. Also, the medicine reduces the tone of blood vessels, mainly vessels located in the skin, kidneys and the brain. It helps to relax the venous walls in a small circle circle, reducing pressure in it.

The use of euphilline makes it possible to improve the blood supply to the kidneys, which leads to an increase in the amount of urine and accelerate its elimination. Also, the drug improves the rheological properties of blood, slowing the aggregation of platelets, which makes erythrocytes more resistant to damage. Reception means can lead to a tocolic effect on the uterus, as well as increase the acidity of gastric juice.

Contraindications

The use of euphilline according to the instructions is contraindicated:

• hyperthyroidism;
• with prostate adenoma;
• ulcerative disease;
• diarrhea;
• in the acute period of myocardial infarction;
• paroxysmal tachycardia;
• in its intolerance;
• during collapse;
• epilepsy;
• disorders in the work of the liver and kidneys;
• extrasystole.

Sideflines

Negative effects of applying Tablets Eufillin:

• hematuria, albuminuria;
• sleep disorders, concern, dizziness, cramps, tremor;
• hypoglycemia (rarely);
• heart rhythm violation, heartbeat.

Against the background of injection therapy possible:

• headache, anxiety, dizziness, excitement, irritability, tremor, insomnia;
• itching skin, rash on the skin, fever;
• tahipne, chest pain, hypoglycemia, albuminuria, strengthening of diuresis, hematuria, increase in sweating, feeling heat in the field of face;
• arrhythmias, tachycardia (including the fetus, if a woman took the drug in the 3rd trimester of pregnancy), heartbeat, cardialigia, reduction of blood pressure, unstable angina;
• nausea, diarrhea, heartburn, gastralgia, vomiting, aggravation of symptoms of peptic ulcer, GER, with long-term use - decrease in appetite.

Side effects are a dose-dependent character, that is, for their relief, it is often sufficient to reduce the dose of the drug.

Local reactions to the introduction of the solution are manifested in the form of hyperemia of the skin, soreness and formation of seals at the injection site.

Children, during pregnancy and breastfeeding

Eufillin is able to penetrate the placenta and in breast milk, so its use during pregnancy and lactation is limited. In childhood, the drug is contraindicated in childhood (up to 3 years, for prolonged oral forms - up to 12 years). Do not apply rectally in children.

special instructions

Be careful when using large quantities of caffean-containing products or drinks during the treatment period.

Medicinal interaction

The instruction reports to enhance the side effects of glucocorticoid, mineralocorticoids and adrenostimulants while receiving with this medicine. Also, the drug is not consumed simultaneously with other xanthin derivatives.

Analogs of Medicine Eufillin

The structure determines the analogues:

1. Eufillin Darnitsa.
2. Aminoophyllin.
3. Aminophyllin-esk.

Analogues have similar effects:

1. Teotard.
2. Neo-theofedrine.
3. Teobiolong.
4. Diprophyllin.
5. Theobromine.
6. Nechek A.
7. Teophylline.
8. Theofedrine-n.

Vacation conditions and price

The average price of Eufillin (pills 150 mg No. 30) in Moscow is 12 - 17 rubles. Recommended by recipe.

Store in a dry, protected from light, at a temperature not higher than 20 ° C. Take care of children. Shelf life - 5 years.

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Eufillin

International non-proprietary title

Aminofillin

Dosage form

Solution for intravenous administration 24 mg / ml, 5 ml

Structure

1 ml of solution contains

active substance -aminoFillin 24.0 mg

auxiliary- water for injections

Description

Transparent colorless or slightly painted liquid

Pharmacotherapeutic group

Preparations for the treatment of obstructive diseases of the respiratory tract. Other preparations for the treatment of obstructive respiratory diseases for system use.

Xanthines

Aminofillin

ATHR03DA05 code

Pharmacological properties

Pharmacokinetics

Bioavailability-90-100%. The time to achieve the maximum concentration in the blood plasma with intravenous administration of 0.3 g-15 min, the maximum concentration in plasma-7 μg / ml. The distribution volume is in the range of 0.3-0.7 l / kg (30-70% of the "ideal" body mass), on average 0.45 l / kg. Communication with plasma proteins in adults - 60%, in newborns - 36%, in patients with cirrhosis of the liver - 36%. Penetrates into breast milk (10% of the adopted dose), through a placental barrier (the concentration in serum of the fetus is somewhat higher than in the serum of the mother).

The brightness properties of aminoophyllin exhibits 10-20 μg / ml concentrations. The concentration of over 20 mg / ml is toxic. The exciting effect on the respiratory center is realized at a lower content of the drug in the blood - 5-10 μg / ml. Metabolized in the physiological values \u200b\u200bof the pH with the release of free theophylline, which is further subjected to metabolism in the liver with the participation of several cytochrome P450 isoenzymes. As a result, 1,3-dimethyl ocheric acid is formed (45-55%), which has pharmacological activity, but is inferior to theophylline in 1-5 times. Caffeine is an active metabolite and is formed in small quantities, with the exception of premature newborn and children under 6 months, which, due to an extremely long t ½ caffeine, there is its significant accumulation in the body (up to 30% of those such for aminoophylline).

Children over 3 years and adult caffeine cumulation phenomenon is absent. Half-life in newborns and children up to 6 months. - more than 24 hours; in children over 6 months-3.7 h; in adults-8.7 h; "Smokers" (20-40 cigarettes per day) - 4-5 h (after refusal of smoking normalization of pharmacokinetics after 3-4 months); In adults with chronic obstructive diseases of the lungs, the "pulmonary" heart and pulmonary heart failure - over 24 hours is excreted by the kidneys. In newborns, about 50% of theophylline is removed with urine unchanged against 10% in adults, which is associated with the insufficient activity of liver enzymes.

Pharmacodynamics

Broncholitic agent, purine derivative; inhibits phosphodiesterase, increases the accumulation of CAMF in tissues, blocks adenosine (purine) receptors; Reduces the intake of CA2 + through the channels of cell membranes, reduces the contractile activity of smooth muscles.

Relaxing the muscles of the bronchi, increases the mucociliary clearance, stimulates the diaphragm reduction, improves the function of respiratory and intercostal muscles, stimulates the respiratory center, increases its sensitivity to carbon dioxide gas and improves alveolar ventilation, which ultimately leads to a decrease in the severity and frequency of apnea episodes. Normalizing the respiratory function contributes to the saturation of blood with oxygen and a decrease in carbon dioxide concentration.

Enhances the ventilation of the lungs in hypokalemia conditions.

It has a stimulating effect on the activity of the heart, increases the strength and frequency of heart abbreviations, increases the coronary blood flow and the need of myocardium in oxygen. Reduces the tone of blood vessels (mainly of the vessels of the brain, leather and kidney). It has a peripheral ventilating effect, reduces pulmonary vascular resistance, lowers the pressure in the "small" circle circle. Increases renal blood flow, has a moderate diuretic effect.

Expands extrahepatic gallways.

Stabilizes the membranes of fat cells, inhibits the release of mediators of allergic reactions.

Through platelet aggregation (suppresses the activation factor of platelets and PGE2 alpha), increases the stability of erythrocytes to deformation (improves the rheological properties of blood), reduces the thrombosis and normalizes microcirculation. It has a tocolic effect, increases the acidity of the gastric juice.

When used in large doses has an epileptogenic effect.

Indications for use

Astmatic status (additional therapy)

Violation of cerebral circulation on ischemic type (as part of combination therapy)

Left-deceiving deficiency with bronchospasm and respiratory disorder by type of Chein-Stokes

Method of application and dose

Adults:

Intravenously introduced slowly (for 4-6 minutes) from 5-10 ml of 24 mg / ml solution (0.12-0.24 g), which is pre-bred in 10-20 ml of isotonic sodium chloride solution. With the appearance of heartbeat, dizziness, nausea, the rate of administration slows down or go to drip administration, for which 10-20 ml of 24 mg / ml of solution (0.24-0.48 g) is divorced in 100-150 ml of isotonic sodium chloride solution; Impaid with a speed of 30-50 drops per minute.

Parenterally introduced Eufillin to 3 times a day, not more than 14 days.

Higher doses of euphillin for adults: one-time - 0.25 g, daily - 0.5 g

In case of emergency conditions, adults are administered intravenously at a dose of 6 mg / kg, diluted in 10-20 ml of 0.9% NaCl solution, introduced slowly for at least 5 minutes.

With asthmatic status, it is shown in / in drip administration - 720-750 mg.

Children:

The drug is contraindicated to children under 14 due to side effects.

Higher doses for children from 14 to 18 years in / c - one-time 3 MK / kg, daily - 0.25 to 0.5 g.

Side effects

- dizziness, headache, insomnia, excitement, anxiety, irritability, tremor, fever, feeling of tides to face

Heartbeat, tachycardia, arrhythmia, decrease in blood pressure,

up to collapse (with fast intravenous administration), cardialgy, increasing the frequency of angina attacks

- gastralgy, Diarrhea , Nausea, vomiting, gastroesophaginal reflux, heartburn, aggravation of ulcerative disease, diarrhea, decreased appetite (during long-term reception)

- skin rash, itching, increased sweating

Seal, hyperemia, soreness (at the injection site)

- breast pain, Tahipne

Hypoglycemia

Strengthening Diurus, Albuminuria, Hematuria

The frequency of the occurrence of side effects is reduced by reducing the dose of the drug.

Contraindications

Children's age up to 14 years

Hypersensitivity (including to other Ksanthin derivatives: caffeine, pentoxyphylin, theobromine)

Epilepsy

Heavy arterial hyper- or hypotension

Heavy tachyrhythmia

Hemorrhagic stroke

Hemorrhage in retina eye

Carefully:pregnancy, age older 55 years old and uncontrolled hypoteriosis (the possibility of cumulation), sepsis, long-term hyperthermia, gastroesophagalrefluch, ulcerative ulcer of the stomach and duodenal intestine (in history), prostate adenoma.

Medicinal interactions

Ephedrine, beta-adrenostimulants, caffeine and furosemid enhance the effect of the drug. In combination with phenobarbital, diphenin, rifampicin, isoniazide, carbamazepine or sulfinpirazone, there is a decrease in the efficiency of euphilline, which may require an increase in the doses of the drug. The clearance of the drug decreases when it is prescribed in combination with antibiotics of the macrolide group, Lincomycin, allopurinol, cimetidine, isoprenaline, beta-adrenoblockers, which may require a reduction in the dose. Oral estrogen-containing contraceptives, anti-diagracial preparations, intestinal sorbents weaken, and H2-histamine blockers, blockers of slow calcium channels, Mexylene is enhanced (bind to the enzymatic system of cytochrome P450 and slow up the aminoophylline metabolism). In the case of use in combination with enocusacin and other fluoroquinolines, the dose of euphilline is reduced. The drug suppresses the therapeutic effects of lithium carbonate and beta adrenoblockers. The purpose of beta-adrenoblockers - prevents the bright effect of euphilline and can cause bronchospasm. Eufillin potentiates the effect of diuretic drugs by increasing glomerular filtration and reduce the tubular reabsorption. With caution, Eufillin is prescribed simultaneously with anticoagulants, with other derivatives of theophylline or purine. It is not recommended to use eutillin with means exciting the central nervous system (increases neurotoxicity). The drug cannot be used with decompose solutions, not compatible with glucose solutions, fructose and levulose. The pH of the mixed solutions should be taken into account: pharmaceutically incompatible with acid solutions.

Increases the likelihood of the development of side effects of glucocorticosteroids, mineralocorticosteroids (hypernatremia), funds for general anesthesia (the risk of ventricular arrhythmias increases).

With simultaneous use with Eanocxacin, small doses of ethanol, disulfiram, fluoroquinolones, recombinant interferon alpha, methotrexate, mexylenetic, conpaphenon, thiabendazole, tickopidine, verapamil and influenza vaccination The intensity of the aminoophylline can increase, which may require a reduction in its dose.

special instructions

The drug is prescribed with caution, under the constant supervision of the doctor, patients:

With pronounced disorders of the liver and kidney function (liver and / or renal failure)

Ulcerative stomach and duodenal disease (in history), when bleeding from the gastrointestinal tract in a recent history of the gastrointestinal tract

With severe coronary failure (acute phase of myocardial infarction, angina)

With a common atherosclerosis of vessels

With hypertrophic obstructive cardiomyopathy

With frequent ventricular extrasystole

At elevated convulsive readiness

With uncontrolled hypothyroidism (the possibility of cumulation) or thyrotoxicosis

With long hyperthermia

With gastroesophageal reflux

With prostate hypertrophy.

Pregnancy and lactation

The use of euphillin during pregnancy can lead to the creation of the fetal and newborn potentially dangerous concentrations of theophylline and caffeine. Newborn whose mothers during pregnancy (especially the III trimester) were received by Eufillin, need medical supervision, to control possible symptoms of intoxication with methylksanthines. The prescription of the drug during pregnancy requires a thorough assessment of benefits for the treatment of mothers and potential risk for the fetus, is made only by extreme life indications.

Breastfeeding during the reception of the drug should be stopped.

Features of the influence of the drug on the ability to control the vehicle or potentially hazardous mechanisms

Given the possibility of the development of side effects of the drug, it follows during the treatment period to refrain from managing motor vehicles and potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Overdose:

Symptoms: Anorexia, diarrhea, nausea, vomiting, pain in the epigastric area, gastrointestinal bleeding, tachycardia, ventricular arrhythmia, tremor, generalized convulsions, hyperventilation, sharp decrease in blood pressure.

Treatment: Cancellation of the drug, stimulation of its elimination from the body (forced diuresis, hemosorption, plasmorbation, hemodialysis, peritoneal dialysis) and the purpose of symptomatic means. To relieve seizures used diazepams (in injections). It is impossible to use barbiturates. In pronounced intoxication (the content of euphilline more than 50 g / l) is recommended by hemodialysis.

Release form and packaging