What is Kip: instructions for use. Kip: description, composition, instructions for use for children Kip immune drug

"KIP", the instructions for use of which speak of its immunostimulating properties, increases specific immunity, increases the amount of immunoglobulins and antibodies to enterobacteria and enteroviruses.

Composition and release form

The drug “KIP”, the instructions show this, is a lyophilized protein solution containing immunoglobulins of the classes IgG, IgA, IgM, isolated from human blood plasma tested for the absence of antibodies to the human immunodeficiency virus HIV-1 and HIV-2, antibodies to the hepatitis virus C (HCV) and hepatitis B virus surface antigen (HBsAg).

Available in bottles containing 300 mg of protein (one dose, 5 ml). Five bottles per pack with instructions for use. Some people are trying to purchase “KIP” candles; the instructions for use do not provide information about this form of release.

Pharmacological properties

The active principle of the drug is the immunologically active fraction of human serum proteins, containing immunoglobulins of classes G, A, M. Immunoglobulins have a high titer of antibodies against a wide range of viruses and bacteria of various classes, which ensures the effective therapeutic effect of the drug.

After oral administration, the drug "KIP", the instructions for use explains, has a local effect in the lumen of the small and large intestine, blocking the receptors of microbial cells, thereby reducing the adsorption of microbes on the epithelial cells of the intestinal mucosa and inhibiting the proliferation of adsorbed microbial cells, weakening or preventing the development infectious process.

Pharmacokinetics of the drug "KIP"

The medicine, as the instructions for use explain, exhibits its effect within several days after administration. Immunoglobulins and their fragments, which retain serological activity, are found both in the contents of the colon and in coprofiltrates for several days after using the drug.

Medicine "KIP" - what is it prescribed for?

CIP - Complex Immunoglobulin Preparation - is prescribed to children from the age of one month and to adult patients for the treatment of acute infectious intestinal lesions, microflora imbalance (developed as a result of long-term exposure to increased background radiation, antibiotic therapy, chemotherapy).

The instructions for use and expert reviews recommend prescribing the drug “KIP” for preventive purposes, to prevent infectious diseases in patients suffering from acquired immunodeficiency, as well as as a means of immunocorrective therapy in children of the first years of life (weak, premature, forcedly deprived of breastfeeding and located on artificial).

Indications for children

Instructions for use for children, reviews from pediatricians, prescribe the medicine “KIP” in the following cases:

• intestinal dysbiosis and intestinal infections caused by enterobacteria;
• immunocorrective therapy for reduced immunity (including chronic gastrointestinal diseases);
• chronic enterocolitis;
• complex therapy of allergic dermatoses combined with intestinal dysfunction.

Medicine "KIP" - instructions for use

For children and adult patients, 1 dose is prescribed orally - the contents of the ampoule 1-2 times a day for a 5-day course, on an empty stomach 30 minutes before meals.

Complex immunoglobulin preparation (CIP), unlike other immunoglobulins, is used orally (per os). The dry powder contained in the bottle (1 dose) is diluted with a portion of boiled water at room temperature. The metal cap along with the rubber stopper covered by it is first removed from the bottle, after which a portion of 5 ml of water is poured into the bottle and the mixture is mixed by light shaking. The result should be a colorless, transparent liquid. The presence of opalescence does not mean that the solution is unsuitable for use. KIP is taken 30 minutes before meals (on an empty stomach) 1 time per day, one serving for a 5-day course. In severe acute forms of intestinal infectious lesions, the daily dose of globulins can be increased by 2-3 times.

In case of chronic pathology, 5-6 months after the end of the course of treatment, it is recommended to conduct a second course. It is possible to use CIP in combination with antibiotics, chemotherapy, and bacteriophages.

When treating acute forms of intestinal infectious lesions and correcting biocenosis, it is advisable to combine the drug with dental agents, other bacterial preparations, probiotics, as well as bacteriophage viruses narrowly focused on specific pathogens.

Precautions for use

The drug "KIP" cannot be used: if the integrity of the bottle is damaged or there is no labeling, if there are coarse foreign inclusions, if it has been changed; physical properties of the drug, in case of violation of the temperature regime of storage. The administration of the drug is registered in the established accounting forms, indicating the batch number, expiration date, manufacturer, date of administration, dose and nature of the reaction to the administration of the drug (if it develops).

Side effect

Allergic reactions in the form of a rash are possible. In this case, the drug is continued against the background of antihistamines. If polymorphic rashes occur, treatment can be continued under the cover of antihistamines. Each administration is registered in the established accounting forms, indicating the batch number, control number, expiration date, manufacturer, date of administration and the nature of the reaction to the administration.

Contraindications

The instructions for use do not recommend taking the drug “KIP” if you have a history of allergic reactions to the administration of human immunoglobulin:

• anaphylactic shock;
• Quincke's edema;
• rash.

Use during pregnancy and lactation

There have been no studies on the use of the drug in women during pregnancy and breastfeeding, so the drug “KIP” is prescribed to pregnant and lactating women with caution when the potential benefit to the mother outweighs the potential risk to the child.

Instructions for use

Description

The dispensing of an immunobiological medicinal product IS CARRIED OUT ACCORDING TO A DOCTOR'S PRESCRIPTION and IF THE BUYER HAS A THERMAL CONTAINER in which the medicinal product is placed, the delivery of this medicinal product to a medical organization, subject to storage in a special thermal container, should not exceed 48 hours after its purchase.

Active ingredients

Release form

Compound

Active ingredient: Human immunoglobulin normal (Immunoglobulin human normal) Active ingredient concentration (mg): 300

Pharmacological effect

CIP is a lyophilized protein solution containing immunoglobulins of the classes IgG, IgA, IgM, isolated from human blood plasma tested for the absence of antibodies to the human immunodeficiency virus HIV-1 and HIV-2, antibodies to the hepatitis C virus (HCV) and the surface antigen of the virus hepatitis B (HBsAg). The technology for obtaining the drug involves two special stages of inactivation of possibly present viruses. The active principle of the drug is the immunologically active fraction of human blood serum proteins containing immunoglobulins of classes G, A, M. Immunoglobulins have a high titer of antibodies against a wide range of viruses and bacteria of various classes, which ensures effective therapeutic effect of the drug. After oral administration, CIP has a local effect in the lumen of the small and large intestine, blocking microbial cell receptors, thereby reducing the adsorption of microbes on the epithelial cells of the intestinal mucosa and inhibiting the proliferation of adsorbed microbial cells, weakening or preventing the development of the infectious process.

Pharmacokinetics

Immunoglobulins and their fragments, which retain serological activity, are found both in the contents of the colon and in coprofiltrates for several days after taking the drug.

Indications

As part of complex therapy for the treatment of viral and bacterial intestinal infections in children from 1 month and adults.

Contraindications

History of allergic reactions to human immunoglobulins.

Precautionary measures

Use during pregnancy and breastfeeding

There have been no studies on the use of the drug in women during pregnancy and lactation, so CIP is prescribed to pregnant and breastfeeding women with caution when the potential benefit to the mother outweighs the potential risk to the child.

Directions for use and doses

After opening, add 5 ml (1/2 tablespoon) of boiled water at room temperature to the bottle. The drug is dissolved with gentle shaking. Apply 1-2 doses (bottle) orally 2-3 times a day, depending on the patient’s age and severity of the disease, 30 minutes before meals for 5 days. If necessary, the course of treatment is repeated. The drug cannot be used if there is no label on the bottle or if there is incomplete information on it, as well as if there are cracks in the bottles.

If the condition allows, take your child to the doctor for a diagnosis. If you have an elevated temperature or weakness, call an ambulance immediately.

The pharmaceutical industry does not have products designed to eliminate rotavirus. Treatment boils down to increasing immunity and improving digestion.

KIP successfully solves the problem with immunoglobulin - it forms the basis of the drug.

Kip for the prevention of intestinal flu

CIP is effective in preventing rotavirus. It is an immunostimulant that protects children's bodies from rotavirus infections.

Adults are prescribed for low immunity or problems with intestinal microflora.

The product is especially useful for children. The immunoglobulins contained in the drug have an effect (similar to that of the mother) on the infant’s body. Breastfed children rarely suffer from acute respiratory diseases.

Scheme for using CIP for the purpose of prevention

CIP for the prevention of rotavirus is used according to the scheme for infants: bottle-fed children need special preventive measures.

CPI is prescribed between the incubation period and the onset of the disease. The duration of use depends on the age and condition of the body. The maximum course of administration is five days, one jar per day. In difficult cases, the doctor will double the dose.

Add 0.5 tablespoon of boiled water to the powder. The resulting solution is shaken and drunk. The package is designed for one patient. The product does not have an unpleasant odor or taste - there should be no difficulties in taking it.

How does this remedy work on the body?

The effect of the drug appears after use. The temperature drops, nausea goes away, and digestive problems disappear.

The instructions say that the instrument is intended for children under fourteen years of age. When rotavirus enters the body, adults experience discomfort. The remedy will benefit them. Admission rules are the same as for children.

If there is no label indicating the composition of the drug and the shelf life, it should not be used. Cracks and other defects on the bottles indicate improper storage.

Does the drug have side effects and contraindications?

As a result of consumption, there is a risk of minor rashes. Consult your doctor for advice and prescription of antihistamines.

Contraindications:

1. Allergy to immunoglobulin.
2. CIPs are prescribed cautiously to pregnant and breastfeeding mothers due to lack of research.

How does the drug interact with other medications?

The complex immunobiological drug is used together with antibiotics, chemotherapy, and antibacterial drugs.

The instrumentation is stored in the refrigerator at a temperature from plus two to eight degrees. Shelf life is three years.

The benefits and harms of immunostimulants

Immunostimulants are used in doses. Otherwise, the drugs destroy the body’s immunity.

The body needs time to develop immunity. A complex immunobiological drug allows you to adapt to unfavorable conditions. CIP is recommended for children starting from the first month of life.

Children's illnesses are always stressful for parents. Calling a doctor, going to the pharmacy, taking the drug and waiting for the effect is a common situation with viral and bacterial infections. These diseases are quite common and can not only be treated as a fact, but also prevented. This is exactly what a complex immunoglobulin preparation is suitable for. Abbreviated as KIP. Let's take a closer look at this drug.

Effect of the drug

KIP belongs to the category of immunological drugs. Its action is carried out due to the presence of human blood serum proteins, which contain immunoglobulins G, A, M. They begin their action upon absorption in the large and small intestines. By blocking the proliferation of microbial cells (such as salmonella, candida, etc.), the inflammatory process is slowed down or prevented. Due to this, the drug is highly effective in treatment.

When using a complex immunoglobulin preparation (CIP), antimicrobial, immunostimulating and antidiarrheal effects are noted. It also helps restore optimal intestinal microflora.

Use in children and in what cases

Due to the safety of the drug KIP, it is prescribed to children. Admission is allowed from 1 month of the baby’s life and is intended for up to 14 years.
So, KIP will be prescribed in the following situations:

• For viral and bacterial infections, including the gastrointestinal tract.
• For intestinal dysbiosis, often associated with the development of pathogenic flora.
• For allergic dermatitis that begins with intestinal dysfunction.
• With reduced immunity, which is manifested by frequent acute respiratory infections.

But it is worth noting that this drug is prescribed as part of a complex treatment. The use of instrumentation alone is often not enough. Consult your doctor before use.

Form of release of the drug and composition

CIP is available in the form of a dry powder, packaged in glass bottles of 5 ml (1 dose). There are 5 of them in one cardboard package, and instructions for use are also included. There are no other forms of release available at this time.

One dose of the drug KIP contains 300 mg of protein, of which 50-70% are immunoglobulin G, Ig M15-25% and Ig A 15-25% of humans. Glycine (aminoacetic acid) is used as a stabilizer - 150 mg.

Application

Before use, it is necessary to prepare a suspension from dry powder. To do this, add 5 ml of boiled water to the bottle. This is half a tablespoon. Close tightly with a production cap and shake lightly. It is necessary to achieve complete dissolution of the drug. As a rule, 3-5 minutes are enough for this. The finished solution is colorless and transparent, slight foam formation is possible.

Prescribe CIP 1 dose 1-2 times a day for 5 days. In acute forms of intestinal infections, the dose is increased up to 3 times. When treating chronic pathologies, the course is repeated every 6 months. The exact dosage is determined by the attending physician depending on the age and condition of the patient. For maximum effectiveness, CIP is used 30 minutes before meals. An opened bottle is not subject to further storage.

It is strictly forbidden to take the drug in the following cases:

• Violation of the integrity of the bottle.
• Unreadable markings.
• Presence of foreign inclusions.
• If the storage temperature conditions are not observed.

According to studies, no adverse events were found when using CPI with other drugs. It is relatively possible to use it in combination with antibiotics, bacteriophages and probiotics.

Side effects

In most cases, the drug is well tolerated by children. But if you are prone to allergic reactions, a rash is possible. In this case, antihistamines are prescribed and the issue is discussed with the attending physician about the further method of taking the drug or stopping it.

Contraindications

A history of allergic reactions (skin rash, angioedema, anaphylactic shock) regarding immunoglobulins or other products containing human blood.

Storage conditions and price

The medicine should be stored in a dry place at a strict temperature of 2-8 degrees. During transportation, it is necessary to maintain a temperature of up to 10 degrees.

Average price for instrumentation in Russia from 800 to 1100 rubles per package, which is enough for 1 full course.

Analogues

Among domestic and foreign manufacturers, we can only talk about Pentaglobin as a complete analogue of instrumentation. The only difference is in the method of administration: CIP is used orally, Pentaglobin is administered intravenously. It is produced in Germany by Biotest Pharma. Its price is 10 times higher than the instrumentation.

In conclusion, it is worth noting that any drug (including CIP) in children is used only after a doctor’s prescription. In this case, it is necessary to strictly adhere to the dosage, remain vigilant and monitor the reaction.

Latest update of the description by the manufacturer 31.07.1998

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Active substance:

ATX

Pharmacological group

Nosological classification (ICD-10)

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Composition and release form

1 bottle of lyophilized powder for the preparation of a solution for oral administration contains 300 mg of immunoglobulin (1 dose); per pack 5 pcs., in a cardboard box.

pharmachologic effect

pharmachologic effect- immunostimulating.

Increases specific immunity, increases the content of immunoglobulins and antibodies to enterobacteria (Shigella, Salmonella, Escherichia, etc.).

Indications of the drug Immunoglobulin complex drug (ICP)

Acute intestinal infections, dysbacteriosis (after exposure to radiation, chemotherapy), prevention of infectious diseases in persons with acquired immunodeficiency, immunocorrective therapy in children of the first years of life (premature, weakened, bottle-fed) and persons with a reduced immune status (disabled, elderly) .

Contraindications

History of an allergic reaction (Quincke's edema, rash, anaphylactic shock) to the administration of human immunoglobulin.

Side effects

Polymorphic rashes.

Interaction

Possible combination with antibiotics, synthetic chemotherapeutic drugs, bacteriophages.

Directions for use and doses

Orally, 30 minutes before meals (the powder is first diluted in boiled water at room temperature: water is added to the contents of the bottle to half the volume and mixed with gentle shaking until a colorless transparent liquid is obtained - opalescence is allowed) 1-2 times a day for 5 days.

special instructions

If polymorphic rashes occur, treatment can be continued under the cover of antihistamines. Each administration is registered in the established accounting forms, indicating the batch number, control number, expiration date, manufacturer, date of administration and the nature of the reaction to the administration.

Storage conditions for the drug Immunoglobulin complex drug (ICP)

In a dry place, protected from light, at a temperature of 2-10 °C.

Keep out of the reach of children.

Shelf life of the drug Immunoglobulin complex drug (ICP)

3 years.

Do not use after the expiration date stated on the package.

Synonyms of nosological groups

Category ICD-10	Synonyms of diseases according to ICD-10
D84.9 Immunodeficiency, unspecified	Autoimmune disease
	Autoimmune diseases
	Severe immunodeficiency
	Immune deficiency
	Immunodeficiency
	Immunodeficiency diseases
	Immunodeficiency states due to surgery
	Immunocorrection for cancer
	Immunomodulation
	Infections in immunocompromised patients
	Correction of immune deficiency
	Correction of immunodeficiency conditions
	Correction of weakened immunity
	Correction of weakened immunity in immunodeficiency states
	Immunity disorder
	Impaired immune status
	Immune system disorder
	Primary immunodeficiency conditions
	Primary immunodeficiency
	Pneumonia in immunodeficiency states
	Maintaining immunity
	Decreased defenses
	Decreased immunity
	Decreased immunity due to colds and infectious diseases
	Decreased immune status
	Reduced resistance to infectious diseases
	Reduced resistance to infectious and colds
	Reduced body resistance
	Reduced immunity
	Predisposition to colds
	Acquired immunodeficiency
	Radiation immunodeficiency
	Development of immunodeficiency
	Immune dysfunction syndrome
	Immunodeficiency syndrome
	Primary immunodeficiency syndrome
	Decreased body defenses
	Decreased immunity
	Decreased immune defense of the body
	Decreased local immunity
	Decreased overall body resistance
	Decrease in cellular immunity indicators
	Decreased resistance to infections in children
	Decreased body resistance
	Reduced body resistance
	Reduced immunity
	State of immunodeficiency
	Severe secondary selective immunodeficiency
	Immune suppression
K63.8.0* Dysbacteriosis	Bacterial dysbiosis
	Viral dysbiosis
	Restoration of intestinal flora
	Deficiency of lactic acid and probiotic microorganisms
	Diarrhea during antibacterial therapy
	Dysbacteriosis
	Intestinal dysbiosis
	Intestinal dysbiosis
	Correction of intestinal microflora
	Disturbance of normal intestinal microflora
	Disturbance of the balance of intestinal microflora
	Disturbance of intestinal flora
	Disorders of the physiological flora of the large intestine
	Disorders of the physiological flora of the small intestine
	Normalization of intestinal microflora
Z29.1 Preventive immunotherapy	Vaccination against viral infections
	Vaccination of donors
	Vaccination and revaccination
	Vaccination of newborn children
	Vaccination against hepatitis B
	Immunoprophylaxis
	Correction of immune status
	Therapeutic and preventive immunization
	Preventive immunization
	Specific immunoprophylaxis
	Stimulation of nonspecific immune processes
Z54 Convalescent period	Recovery period
	Recovery period after illness
	Recovery
	Recovery from flu and colds
	Recovery after illnesses
	Insufficiency of mineral salts during convalescence
	Recovery period after illness
	Recovery period after illness
	Recovery period after illnesses
	Recovery period after illnesses and surgeries
	Recovery period after serious illnesses
	The recovery period after illnesses
	Rehabilitation period
	Recuperation period after infectious diseases
	Convalescence period
	The period of convalescence after surgery and infectious diseases
	The period of convalescence after illnesses
	The period of convalescence after prolonged infections
	The period of convalescence after serious illnesses
	The period of convalescence after severe infections
	Rehabilitation period
	Convalescent states
	Convalescence
	Convalescence after illness
	Convalescence after infectious diseases
	Convalescence after debilitating diseases
	Convalescence after infectious diseases
	Convalescence with increased blood loss
	State of convalescence after illness