How to do vitamin B6. Recipes (vitamins, folic acid, nicotinic acid, tavergl, diphedrol, suprastin, etc.). What is the drug vitamin B6 dosage and application
Pyridoxine hydrochloride, which is known as vitamin B6, is necessary for the coordinated work of all organs and systems of a healthy person. Pyridoxin does not accumulate in the body, so it is necessary to fill its drawback using food or vitamin complexes.
Why do you need vitamin B6? What will it lead to its lack, how to correctly replenish the lack of this important substance? These and other questions you will find the answer in this article.
Pyridoxine participates in almost all the processes of the body, performing many important functions.
- Like others, Vitamin B6 contributes to the proper exchange of substances. That is, it enhances the splitting of fats, and successfully applies in the fight against overweight;
- Participates in the formation of serotonin, hormone, which provides good mood and positive emotions. That is why pyridoxine is called vitamin joy;
- Able to regulate blood sugar levels preventing the development of diabetes;
- Reduces the risk of blockage of blood vessels and arteries, thereby normalizing blood pressure;
- Quicks the amount of cholesterol and lipids to normal, reducing the risk of cardiovascular diseases;
- With it, the correct operation of the nervous system is becoming correct. After all, it helps to be produced by active substances, with the help of which the nerve impulses are transmitted;
- Helps excess fluid to get out of the body. Thus, it prevents the occurrence of edema and significantly reduces the likelihood of kidney stones;
- Increases mental and physical performance;
- Helps female sex hormones to be in the desired equilibrium for the proper operation of the reproductive system;
- Stops premature cell aging.
Pyridoxin plays an important role in the process of producing antibodies. The right amount of vitamin B6 strengthens immunity, increasing the protective properties of the body and reducing the risk of infections.
Health of women and pyridoxin
Vitamin B6 is absolutely necessary for everyone. However, the representatives of the beautiful half of humanity are particularly susceptible to health problems in its lack. What is it useful to pyridoxine women and why is it called female vitamin?
Insufficient number of vitamins of a group in a woman's body first affect the appearance. Hair loss, poor skin condition, nail fragility - an incomplete list of problems that a woman will face due to the deficit of pyridoxine.
Vitamin B6 helps to facilitate the symptoms of PMS and reduce pain during the menstrual cycle. For women who take contraceptives, it is doubly needed. After all, after making a contraceptive, the amount of vitamin B6 decreases by 20 percent! In the event that if the body has experienced a deficiency of pyridoxine, the risk of mental disorders is great.
If the woman's body regularly arrives in the body, the required amount of vitamin B6, the risk of oncological diseases is reduced several times.
Many are interested in the question, which is influenced by Vitamin B6 in the period of tooling the child.
Since Pyridoxin participates in the formation of red blood cells and nerve cells, its role increases during the formation of vital organs and kid systems. In the complex C and it prevents the cutting of the uterus, which reduces the likelihood of miscarriage. The future mother is especially important to obtain vitamin B6 in the necessary quantity during the formation of the brain in the child.
The need for vitamin
The amount of vitamin B6 is necessary per day depends on age, gender, addictions in the food, the presence of bad habits, etc.
Pregnant and nursing women need Pyridoxine. They need up to 4 mg vitamin B6 per day. Adult - up to 2, 5 mg. Babies and children under the age of 14 will be enough from 0.3 to 1 mg vitamin B6. For adolescents, the recommended daily dose will be up to 1, 6 mg.
- Pregnant women;
- Women using hormonal contraceptives;
- People suffering from obesity;
- Women before the start of the menstrual cycle;
- Abusive spirits and smoking;
- Patients with immunodeficiency virus;
- People who take antidepressants and steroid-based preparations;
- In the period of enhanced physical and intellectual loads.
The increased need of vitamin B6 is celebrated in adolescents who cannot cure the angry rash.For a better result, it is necessary to use in the Pyridoxine complex and ointment with its content.
How to recognize vitamin B6 deficiency
Symptoms The lack of pyridoxine arise as soon as the body "felt" its shortage. The presence of one or more symptoms does not always talk about the deficiency of vitamin. It can also signal about the development of any disease.
If pyridoxine hypovitaminosis in the body, sooner or later it will begin to manifest. As a rule, people note such symptoms of vitamin B6 deficiency:
- Lack of appetite. Frequent nausea, which can be accompanied by vomiting;
- Poor mood manifested in irritability and anxiety;
- Sleep disturbance;
- Fragility and loss of hair;
- Development of anemia;
- The appearance of dermatitis, the general deterioration of the condition of the skin;
- Development of conjunctivitis;
- Thickening of blood, which contributes to the appearance of clots and blockage of blood vessels;
- Possible inflammatory process on the mucous membrane in the oral cavity;
- The appearance of convulsion and spasm in the muscles. Especially bright this symptom manifests itself in young children.
The lack of vitamin B6 affects the decrease in the natural protective functions of the body. If you do not fix the deficiency of pyridoxine on time, a violation of the water-salt balance is possible, which will lead to edema. Over time, even more serious consequences will appear: a failure in the work of nervous and cardiovascular systems.
Medical nutrition
Almost all natural vitamins and the trace elements necessary for the proper operation of organs and systems enter the body with food. To fill the lack of vitamin B6, it is necessary to include in the daily diet rich in pyridoxine.
The largest amount of vitamin B6 is in such products:
- Liver;
- Coarse bread and sprouted cereals;
- Yolk eggs;
- Red fish;
- Nuts.
It is great in vegetable oil, as well as in juice - grape, orange and tomato. Especially useful juices prepared immediately before use, because when preserving, products are losing up to 60% of vitamins.
If you have breakfast to eat a portion of buckwheat, rice or milf prepared as a porridge, then the daily need for pyridoxine will be provided. All green vegetables, and cabbage - champions on the content of the trace element. A little inferior to them lemons, oranges, and a sweet cherry, but in these fruits vitamin B6 is also in small quantities.
Pyridoxin is present in milk, but after heat treatment, its content is reduced by half.
To provide the body with the help of food with the necessary amount of vitamins, you need to know not only what to eat, but also how to prepare these products. As soon as food is exposed to heat treatment, the number of any vitamin in it begins to decrease.
You need to know some subtleties of cooking to keep the maximum amount of natural vitamin B6 in food:
- Almost all useful vitamin substances with culinary processing are moving into water. Therefore, it is necessary to eat bouothings in which meat or fish was boiled.
- Frozen vegetables and fruits can save only half pyridoxine.
- Various dishes are better prepared for a couple, so you can achieve greater vitamin preservation.
Approved
Order of the Chair
Monitoring committee medical and
Pharmaceutical activity
Ministry of Health
Republic of Kazakhstan
From "____" ______________ 201__
№ ________________
Instruction
for medical use of the drug
Pyridoxine Darnitsa (Vitamin B6-Darnitsa)
Tradename
Pyridoxin - Darnitsa (Vitamin B6 - Darnitsa)
International non-proprietary title
Pyridoxin
Dosage form
Solution for injection 5%
Structure
1 ml of solution contains
active substance - pyridoxine hydrochloride 50 mg
excipients - Dinatari Edetat, water for injection.
Description
Transparent colorless or slightly painted liquid.
Pharmacotherapeutic group
Other vitamins in pure form. Pyridoxine.
ATH Code A11NA02.
Pharmacological properties
Pharmacokinetics
Metabolized in the liver with the formation of pharmacologically active metabolites (pyridoxalphosphate and pyridoxaminophosphate). Pyridoxal phosphate with plasma proteins is associated with 90%. Well penetrates all the fabrics. Accumulates mainly in the liver, less - in the muscles and the central nervous system (CNS). Penetrates through the placenta, excreted into breast milk. Half-exploration time (T1 / 2) - 15-20 days. It is excreted by the kidneys (with intravenous administration - with bile 2%), as well as during hemodialysis.
Pharmacodynamics
Pyridoxine hydrochloride (vitamin B6) is contained in plants and organs of animals, especially in crude grains of cereals, in vegetables, meat, fish, milk, liver cod and cattle, egg yolk. A lot of vitamin B6 is contained in yeast. The need for vitamin B6 is satisfied with food; In part, it is also synthesized by the intestinal microflora.
It plays an important role in metabolism, it is necessary for the normal functioning of the central and peripheral nervous system, participates in the synthesis of neurotransmitters. In phosphorylated form, the processes of decarboxylation, reamincing, deamination of amino acids, is involved in the synthesis of protein, enzymes, hemoglobin, prostaglandins, the exchange of serotonin, catecholamines, glutamic acid, gamma-aminobacing acid (GABA), histamine, improves the use of unsaturated fatty acids, reduces cholesterol levels and blood lipids improves the reduction of myocardial, contributes to the conversion of folic acid into its active form, stimulates hemopoies. In atherosclerosis, vitamin B6 improves lipid exchange.
Pyridoxine during atherosclerosis and diabetes mellitus reduces the content of glycosylated hemoglobin, in addition, pyridoxine acts as a diuretic: helps reduce increased blood pressure.
It has been established that pyridoxine has a positive effect on the production of norepinephrine and serotonin, increasing their products in depression, which is associated with its participation as a draw-decarboxylase drawer in the process of synthesis of catecholamines.
Pyridoxin can increase the coagulation time and inhibit platelet aggregation, which is probably due to the binding of pyridoxalphosphate with fibrinogen and with specific amino groups on the surface of platelets.
Indications for use
Gimito and vitamin B6
Complex treatment of toxicosis of pregnant women, atherosclerosis, anemia (including sideroblastic), leukopenia, diseases of the nervous system (radiculitis, neuritis, neuralgia, Parkinsonism, Little's disease), depression of involutionary age, acute and chronic hepatitis, serybore-like and non-chronic dermatitis, swaying deprivable, Neurodermitis, psoriasis, exudative diathesis, when removing from the binge and hangover syndrome
Air and sea disease
Meniery's disease
Prevention or reduction of toxic effects (especially polynevrit) in the treatment of anti-tuberculosis drugs
Treatment of pyridoxin-dependent seizures.
Method of application and dose
The preparation of pyridoxine-Darnitsa is introduced intramuscularly, intravenously or subcutaneously in cases where oral administration is impossible.
The solution is prepared immediately before use - a one-time dose of the drug is divorced in 1-2 ml of water for injection or 0.9% solution of sodium chloride.
Adults.
Cideroblastic anemia: the drug is prescribed intramuscularly in a daily dose of 100 mg (2 ml) 2 times a week. At the same time, it is recommended to take folic acid, riboflavin, vitamin B12.
Overdose of the drugs of the isoniazide group: for each 1 g of an overview drug administered intravenously 1 g (20 ml) pyridoxine with a speed of 0.5 g / min. In case of overdose of isoniazid, over 10 g, pyridoxine is administered intravenously at a dose of 4 g (80 ml), and then intramuscularly - 1 g (20 ml) of the drug every 30 minutes. Shared daily dose - 70-350 mg / kg.
Parkinsonism: the drug is prescribed intramuscularly at a dose of 100 mg (2 ml) per day. Course of treatment - 20-25 days. After 2-3 months - a re-course. According to another treatment regimen: the drug is prescribed intramuscularly in the initial daily dose of 50-100 mg (1-2 ml), and then a daily dose increases by 50 mg (1 ml) and adjusted to 300-400 mg (6-8 ml) per day unite. Treatment is carried out by courses in 12-15 days.
Other readings: The preparation is prescribed in a daily dose of 50-100 mg (1-2 ml) for 1-2 administration.
Pyridoxin-dependent convulsions: the drug is prescribed intramuscularly or intravenously in a dose of 10-100 mg (1-2 ml) per day. Intravenously introduced at a speed of 25 mg / min. Maximum doses for children are not installed.
Side effects
Tachycardia, heart pain
Headache, dizziness, drowsiness, excitement, violation of coordination, paresthesia, numbness in the limbs, the appearance of a feeling of compression in the limbs - the symptom of "stockings and gloves", the loss of consciousness and the development of convulsion with rapid intravenous administration
Labored breathing
Nausea, pain in the epigastric region, heartburn, increase the gastric secretion
Decrease in folic acid
Anaphylactic shock, urticaria, rash, itching, skin hyperemia, dermatitis, swelling of quinque, photosensitization
Depression of lactation in the lactogen period (sometimes used for therapeutic effect)
Changes in the place of administration, including hyperemia, itching, burning in place of injection
Weakness, fever.
Contraindications
Hypersensitivity to the components of the drug
Ulcerative ulcer of the stomach and duodenal intestine (due to the possible increase in the acidity of the gastric juice)
Liver diseases leaking with severe functional failure
Coronary artery disease.
Medicinal interactions
Diuretics - with the combined application with pyridoxine, the action of diuretics is enhanced.
Hormonal contraceptives, cycloserine, penicillamine, isoniazide, hydralazine sulfate, ethionamide, immunodepressants - when combined use with pyridoxine, the latter effect decreases.
Sleeping and sedative means - with a combined application with pyridoxine, a sleeping pill effect is weakened.
Anti-parkinsonic means - with a combined application with pyridoxine decreases the effectiveness of funds for the treatment of Parkinson's disease.
Phenytoin - with a combined application with pyridoxine, the effect of phenytin is weakened.
Corticosteroids - with a combined application with pyridoxin, the amount of vitamin B6 in the body decreases.
Glutamic acid, asparks - with a combined application with pyridoxin increases resistance to hypoxia.
Cardiac glycosides - with a combined application with pyridoxin, the synthesis of contractile proteins in myocardium increases.
Tricyclic antidepressants - with a combined application with pyridoxine, the latter eliminates the side effects of tricyclic antidepressants associated with their anticholinergic activity (dry mouth, urine delay).
Preparations of leftomycetin resorbative action - with a combined application with pyridoxine Last prevents ophthalmic complications that occur with long-term use of resorbative resistivity drugs (syntomicin, chloramphenicol).
It is impossible to mix pyridoxine solution in one syringe with a solution of thiamine (vitamin B1), a solution of cyanocobalamin (vitamin B12), alkaline solutions, iron salts and oxidizing solutions. Pyridoxine injections are desirable to do no earlier than 12 hours after the injection of thiamine.
It is not recommended to mix in one infusion system or in one syringe with such drugs: adrenomimetics, ampicillin sodium salt, amphotericin in ascorbic acid, other vitamins of group B, phytomenadyon, dipyridamole, sodium oxyfferbonicorm, derivatives of phenothiazine (chlorpromazine), furosemide, ethanezilate, Euphillin.
special instructions
Use with caution to patients with ulcerative ulcer of the stomach and duodenal intestine in history (due to a possible increase in the acidity of gastric juice), with functional lack of liver (pyridoxine in large doses can worsen its function).
The exchange of pyridoxine is broken at regular alcohol consumption.
Can lead to a false positive sample on urobilinogen using Erlich reagent
Pregnancy, Lactation
The drug is prescribed during pregnancy during the toxicosis of pregnant women and with vomiting in pregnant women. When prescribing the drug during breastfeeding, lactation is possible.
The drug is used in pediatric practice in the complex treatment of congenital pyridoxin-dependent convulsive syndrome in newborns. Enter intramuscularly and intravenously. Doses and the mode of administration depend on the pathology (see section "Method of application and dose").
Features of the influence of the medicinal product on the ability to control vehicles and other potentially hazardous mechanisms
During treatment, caution should be taken when driven by vehicles and work with complex mechanisms in connection with the possibility of developing side effects from the nervous system.
Overdose
Symptoms. strengthening side effects; violation of the exchange of proteins, carbohydrates and lipids; Degenerative changes in the central nervous system (peripheral neuropathy) and parenchymal organs (violations of the exchange processes associated with a significant decrease in the activity of nicotynamide coenzymes over and NDF and nicotinic acid deficiency). Symptoms of peripheral neuropathy: hyperparseseia, paresthesia, muscle weakness. Sensory neuropathy with a progressive walking violation, a feeling of numbness and tingling in legs and hands, partial baldness, reduction of the body resistance to infections, reducing the activity of an antosvertible blood system is possible. With long-term use in large doses, hypervitaminosis of B6 develops, which is characterized by a sharp decrease in the protein content in muscle tissue and internal organs. In the early stages of Hypervitaminosis B6 may appear: rash on the skin, dizziness, cramps. When canceling the drug, these symptoms disappear.
Treatment. Cancellation of the drug, symptomatic treatment.
Release form and packaging
1 ml in ampoules glass.
5 ampoules along with a knife for opening the ampoules are placed in the contour cellular packaging (cassette). When packing ampoules with a colored rings of a break or with a colorful blunt point, laying knives for opening the ampoules is excluded. Two contour cellular packaging together with the instructions for medical use in public and Russian are placed in a pack.
10 ampoules along with the instructions for medical use in public and Russian languages \u200b\u200band a knife for opening the ampoules are inserted into a box with a corrugated corrugation paper liner. When packing ampoules with a colored rings of a break or with a colorful blunt point, laying knives for opening the ampoules is excluded.
Storage conditions
Store in the original packaging at a temperature not higher than 25 ° C. Do not freeze.
Keep out of the reach of children!
Storage term
Do not use after the expiration date.
Conditions of vacation from pharmacies
On prescription
Manufacturer
Borisov Plant Medperatov RUE (Republic of Belarus)
In the first half of the last century, scientific studies were launched related to vitamin B6, which continue by many scientists to the present. In 1934, Paul Diedo researcher first discovered this vitamin. In 1939, he was first given in 1939, the names generally accepted now - Vitamin B6, Pyridoxine. In 1938, the American researcher was the first isolated pure crystalline water-soluble pyridoxine.
Vitamin B6 is actually a group of vitamins: pyridoxine, pyridoxinals and pyridoxamine, which are closely related to each other and act together (caloricator). We need B6 to form antibodies and red blood cells.
Physico-chemical properties of vitamin B6
By its chemical nature of the substance of the group of vitamin B6 are the pyridine derivatives. It is a white crystalline substance, well soluble in and.
Enemies: long-term storage, water, food processing process, estrogens.
Daily need for vitamin B6
The table shows more detailed data of the daily need of pyridoxine:
| Age / floor | Daily need (mg) |
| Breast children 0-6 months | 0,5 |
| Children from 6 months to 1 year | 0,9 |
| Children from 1 year to 3 years | 1,0 |
| Children 4-6 years old | 1,3 |
| Children 7-10 years old | 1,6 |
| Teenagers young men 11-14 years | 1,8 |
| Teen girls 11-14 years old | 1,6 |
| Yunows 15-18 years old | 2,0 |
| Girls 15-18 years old | 1,7 |
| Men 19-59 years old | 2,0 |
| Women 19-59 years old | 1,8 |
| Men 60-75 years old | 2,2 |
| Women 60-75 years old | 2,0 |
| Men older than 75 years | 2,3 |
| Women older than 75 years | 2,1 |
| Pregnant women | 2,1 |
| Women nursing breasts | 2,3 |
Vitamin B6 helps for proper assimilation of protein and fat. Contributes to the transformation of tryptophan - indispensable amino acids - in. Helps prevent various nervous and skin disorders. Facilitates nausea. Promotes the correct synthesis of nucleic acids that impede aging. Reduces nightmish muscle spasms, seizures of calf muscles, numbness of hands, certain forms of non-general limbs. Acts as a natural diuretic.
People who use squirrel in large quantities need this vitamin (Calorizator). Vitamin B6 can reduce the need for diabetics in insulin, and if its dose is not adjusted, this may lead to a decrease in blood sugar content.
Pyridoxine is useful for the following diseases:
- Leukopenia;
- Anemia;
- Toxicosis during pregnancy;
- Meniery's disease;
- Air and sea disease;
- Hepatitis;
- Diseases of the nervous system;
- Various skin diseases.
Harmful properties of vitamin B6
Pyridoxine is well tolerated in all forms. It has very low toxicity. People with individual intolerance to pyridoxin can develop allergic reactions in the form of urticaria. Harm can apply only with long-term reception in very large doses. In this case, symptoms arise: numbness of limbs, tingling, feeling squeezing, loss of sensuality.
Vitamin B6 digestibility
Vitamin B6 is well absorbed by the body, and its excess is displayed with urine. Announced 8 hours after the reception and how everything should be ashamed, but if not enough in the body, the absorption of vitamin is noticeably deteriorated.
Symptoms of vitamin B6 deficiency:
- Drowsiness, irritability, inhibition;
- Loss of appetite, nausea;
- Dry skin over eyebrows, around the eyes, on the neck;
- Cracks and ulcers in the corners of the mouth;
- Focal hair loss;
- Insomnia;
- Depression;
- Flatulence;
- The appearance of stones in the kidneys;
- Conjunctivitis;
- Stomatitis.
For infants, the following symptoms of pyridoxine deficiency are characteristic:
- Increased excitability;
- Convulsions resembling epilepsy;
- Growth delay;
- Gastrointestinal disorders.
Diseases caused by B6 deficiency: anemia, seborrheic dermatitis, glossite.
Excess vitamin B6 in the body
Usually, pyridoxine is well tolerated in all forms and is quickly excreted in a natural way with urine. But harm can cause large doses of vitamin B6 during prolonged reception. Day doses, starting with 2-10 grams, can cause neurological disorders. Possible symptoms of overpose of vitamin B6 are anxiety in a dream and too vivid dreams of dreams (caloricator). Not recommended more than 500 mg per day.
Interaction of vitamin B6 (pyridoxine) with other substances
Pyridoxine is necessary for proper assimilation. We are necessary for education and compounds.
People suffering from arthritis receiving penicillamine treatment should take additives of this vitamin.
Supplements of this vitamin should not take those who, in connection with Parkinson's disease, take the levodopa preparation.
Vitamin B6 along with vitamins, and has a beneficial effect on the cardiovascular system, warns of ischemia, atherosclerosis and myocardial infarction.
More about Vitamin B6, see the video clip "Organic Chemistry. Vitamin B6 "
P N013203 / 01, P N013203 / 02.
Trade name of the drug:
Magna B 6 ®.Dosage form:
shell tablets, a solution for intake.Structure
Shell-covered tablets
Core pills:
active substances:
magnesium lactate dihydrate * - 470 mg;
pyridoxine hydrochloride - 5 mg;
excipients: Sakharoza - 115.6 mg, heavy kaolin - 40.0 mg, acacia gum - 20.0 mg, carboxypolymethylene 934 - 10.0 mg, talc (magnesium hydrosilicate) - 42.7 mg, magnesium stearate - 6.7 mg.
Tablet shell: Acacia gum - 3,615 mg, sucrose - 214,969 mg, titanium dioxide - 1.416 mg, Talc (magnesium hydrosilicate) - traces, wax Carnubsky (powder) traces.
* - equivalent to the content of magnesium (Mg ++) 48 mg
Ingestion
Active substances:
magnesium lactate dihydrate ** - 186 mg;
magnesium Pidolat ** - 936 mg;
pyridoxine hydrochloride - 10 mg;
excipients: Sodium disulfite - 15 mg, sodium saccharinate - 15 mg, flavoring cherry-caramel - 0.3 ml, purified water to 10 ml.
** - equivalent to the total magnesium content (Mg ++) 100 mg
Description
Oval biconvecake tablets covered with white shell, with a smooth shiny surface.
Solution for receiving inside:
Transparent brown liquid with caramel smell.
Pharmacotherapeutic group
Magnesium preparation.
ATH code: A11JB.
Pharmacological properties
Pharmacodynamics
Magnesium is a vital element that is located in all tissues of the body and is necessary for the normal functioning of cells, participates in most metabolic reactions. In particular, he participates in the regulation of the transfer of nerve impulses and in the contraction of the muscles. The body receives magnesium together with food. The lack of magnesium in the body can be observed in disruption of the power mode (diet) or with an increase in magnesium need (with increased physical and mental load, stress, pregnancy, diuretics). Pyridoxine (vitamin B 6) is involved in many metabolic processes, in the regulation of metabolism of the nervous system. Vitamin B 6 improves magnesium suction from the gastrointestinal tract and its penetration into the cells.
Magnesium content in serum:
Magnesium absorption in the gastrointestinal tract is no more than 50% of the dose taken into the inside. 99% magnesium in the body is inside the cells. Approximately 2/3 of intracellular magnesium is distributed in bone tissue, and the other 1/3 is in a smooth and cross-striped muscle tissue. Magnesium is excreted mainly with urine. With urine, at least 1/3 of the adopted dose of magnesium is excreted.
Indications for use
Melted magnesium deficiency, isolated or associated with other deficient states, accompanied by such symptoms as: increased irritability, minor sleep disorders; gastrointestinal spasms or rapid heartbeat; Increased fatigue, pain and spasms of muscles, feeling of tingling.Contraindications
Carefully
With a moderate degree of renal failure, since there is a risk of hypermagniasia.
Application during pregnancy and in breastfeeding period
Pregnancy
The clinical experience of using the drug in a sufficient number of pregnant women did not reveal any adverse effect on the occurrence of malformations of the fetus or fetotoxic effect.
The drug of Magne B 6 ® can be applied during pregnancy only if necessary, on the recommendation of the doctor.
Breastfall period
Magnesium penetrates breast milk. Applying the drug during lactation and breastfeeding should be avoided.
Method of application and dose
Before taking the drug, you must consult with your doctor.Shell-covered tablets
Adults are recommended to take 3-4 ampoules per day.
Children over 1 year (body weight more than 10 kg), the daily dose is 10-30 mg of magnesium / kg of weight (0.4 - 1.2 mmol of magnesium / kg) or 1-4 ampoules.
The daily dose should be divided into 2-3 receptions, take during meals.
Tablets should be powered by a glass of water.
A solution from ampoules is dissolved in? Glass of water.
Treatment should be discontinued immediately after the normalization of the concentration of magnesium in the blood.
Attention
Self-adhesive ampoules with Magne B 6 ® do not require the use of a sawmill. To open an ampoule, take it for the tip, pre-covering it with a piece of fabric, and break it with a sharp movement first from one pointed end, and then from the other, after sending an open to the first end of the ampoule at an angle into a glass with water, so that the latter is the second The tip of the ampoule was not above the glass. After shaking the second tip of the ampoule, its contents freely fall into the glass.
Side effect
Impaired immune system
Rarely (< 0,01%): аллергические реакции, включая кожные реакции.
Violations from the gastrointestinal tract
An unknown frequency (according to the available data to estimate the frequency of occurrence is not possible): diarrhea, abdominal pain, nausea, vomiting, meteorism.
Overdose
Symptoms
With a normal kidney function, the overdose of magnesium at its reception usually does not lead to the occurrence of toxic reactions. However, in the case of renal failure, the development of magnesium poisoning is possible.
Overdose symptoms, the severity of which depends on the concentration of magnesium in the blood: decrease in blood pressure; nausea, vomiting; oppression of the central nervous system, reducing reflexes; changes on the electrocardiogram; oppression of breathing, coma, stopping heart and palsy of breathing; Anuric syndrome.
Treatment
Rehydration, forced diuresis. In renal failure, hemodialysis is needed or peritoneal dialysis.
Interaction with other drugs
Contraindicated combinations
Combinations that should be taken into account
special instructions
Information for patients with diabetes mellitus: pills covered with shell contain sucrose as an auxiliary substance.In the case of a severe degree of magnesium deficiency or malabsorption syndrome, treatment is starting with intravenous administration of magnesium preparations.
In the case of a concomitant calcium deficiency, it is recommended to eliminate magnesium deficiency before the reception of calcium or food additives containing calcium.
With frequent use of laxatives, alcohol, intense physical and mental loads, the need for magnesium increases, which can lead to the development of magnesium deficiency in the body.
The ampoules contain sulphite, which can cause or enhance the manifestation of allergic type reactions, including anaphylactic reactions, especially in patients with risk groups.
When applying pyridoxine in high doses (more than 200 mg per day) for a long time (for several months or in some cases - years), sensory axonal neuropathy may develop, which is accompanied by such symptoms as numbness, disorders of proprioceptive sensitivity, the tremor of the distal departments limbs and gradually developing sensory ataxia (violation of coordination of movements). These violations are usually reversible and pass after the cessation of vitamin B 6.
The preparation in the form of tablets is intended only for adults and children over 6 years old. For young children (older than 1 year), a drug in the form of a solution for intake is recommended.Impact on the ability to manage vehicles and engage in other potentially hazardous activities
Does not affect. There are no special recommendations.
Form release
Shell-covered tablets10 tablets in PVC PVC / foil aluminum. 5 blisters along with the application instructions are placed in a cardboard pack.
Ingestion
10 ml of the drug in the ampoules of dark glass (hydrolytic class III EP), soldered on both sides, with a fled line and applying two marking rings to each of the sides. 10 ampoules in the packaging liner from the cardboard, together with the instructions for use, are placed in a cardboard pack.
Shelf life
Sheath-covered tablets: 2 years.Solution for receiving inside: 3 years.
The drug cannot be applied after the expiration date.
Storage conditions
Sheath-covered tablets: In the dry, protected from light place at a temperature not higher than 25? p.Solution for receiving inside: In the light-protected place at a temperature not higher than 25? p.
Keep out of the reach of children.
Conditions of vacation
Released without a recipe.Manufacturer
Shell-covered tabletsSanofi Winter industry. 82, Avenue Disinfect, 94250 Gensti - France.
Ingestion Sanofi Winter industry. 82, Avenue Disinfect, 94250 Gensti, France. Cooperal Pharmacetic Frances. Plyasa Lucien Over 77020 Melan, France. Consumer claims to send to the address:
125009, Moscow, ul. Tverskaya, 22.
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